"Napoleon Dynamite" follows the continuation of the adventures of Napoleon Dynamite, a 16-year-old boy convinced that he is destined to be great and has "sweet abilities". He practices his ninja moves, drawing ligers, soul dancing and talking about his "girlfriend in Oklahoma". Kip, is unemployed, 32 years old and still lives at home. He believes he is a catch if anyone would respond to his online chats. Together, Kip and Napoleon live with their Grandma.
At school, Napoleon's friends Pedro and Deb, who thinks that she is going to be Mrs. Dynamite someday, hang out together while Rico Napoleon's uncle lives in a custom van obsessing over his football days in High School. Along for the ride is Rex Kwon Do, a self-proclaimed Martial Arts master.