After living through the Battle of Culloden, Jamie finds himself at the mercy of unforgiving British victors, until a connection from his past provides his only hope of survival. Meanwhile, a pregnant Claire attempts to adjust to life in the modern world of 1940s Boston - and life with Frank.
Jamie leads a lonely life hidden in a cave until Lallybroch is threatened by redcoats; Claire and Frank struggle to coexist in a marriage haunted by the ghost of Jamie.
In prison, Jamie discovers that an old foe has become the warden - and now has the power to make his life a living hell. Over the years, Claire and Frank both put their best foot forward to share a harmonious marriage, but an uninvited guest shatters this illusion, bringing their differences to light.
While serving as groomsman at the aristocratic estate of Helwater, Jamie is reluctantly pulled into the intrigue of a noble British family. In 1968 Scotland, Claire, Brianna and Roger struggle to trace Jamie's whereabouts in history, leaving Claire to wonder if they will ever find him again.
Brianna grapples with life-changing revelations and Claire must help her come to terms with the fact that she is her father's daughter. Roger brings news that forces Claire and Brianna to face an impossible choice.
After decades apart, Jamie and Claire finally reunite and rekindle their emotional and physical bonds. But Jamie's new business dealings jeopardize the couple's hopes for a simple life together.
In the aftermath of a unhappy confrontation, Claire follows her conscience as a surgeon, even though it could put her and Jamie's lives at risk. At the same time, Jamie attempts to evade the reach of the Crown as its representative closes in on his illegal dealings.
Claire returns to Lallybroch with Jamie, where she does not receive quite the reception she was expecting. Unbeknownst to her, Jamie has made some choices in their time apart which will come back to haunt them with a vengeance.
Claire and Jamie leave Scotland, sailing to the West Indies on an urgent quest. But when the superstitious crew looks for someone to blame after a string of bad luck, rescue comes from an unlikely source.
Claire races to discover the source of an epidemic aboard a disease-stricken ship before hundreds of sailors die. And as Jamie locks horns with Captain Raines, Fergus finds himself torn between loyalty and love.
After making a leap of faith, Claire washes up on a seemingly deserted island where survival is her only option. Navigating treacherous waters has crippled the Artemis, so Jamie devises a joyful moment for his crew in the midst of devastating setbacks.
The Artemis finally reaches Jamaica bringing Jamie and Claire that much closer to their goal. During a lavish ball on the island, the Frasers encounter old allies, as well as former adversaries who threaten to derail their mission.
Claire is forced to play a game of cat and mouse with an old adversary as she searches for Young Ian. The Frasers race through the jungles of Jamaica to prevent the unthinkable.