Michael hopes to talk his way out of solitary confinement, while Bellick gets himself into trouble after refusing to mop up a mess. Meanwhile, Susan B. has her sites set on Sucre
as he makes a delivery to Sona. Sofia confronts T-Bag after he makes an offer to Whistler. Also, a mysterious American woman has arrived in Panama in search of Michael.
Due to a political conspiracy, an innocent man is sent to death row and his only hope is his brother, who makes it his mission to deliberately get himself sent to the same prison in order to break the both of them out, from the inside.