Teresa Mendoza has to go on the run and do whatever it takes to survive after the Mexican drug cartel comes after her.
Still reeling from the loss of Güero and her escape to America, Teresa has to fend for herself and avoids being forced into prostitution by proving her worth to Camila. Epifanio's hunt for Teresa leads him to contact Camila. Meanwhile, in Mexico, Brenda, desperately tries to contact Teresa as she and Tony evade Epifanio's hit men.
Camila sends Teresa on a major drug operation to test her loyalty. When Teresa plays a pivotal role in the pickup, she takes a real step toward being trapped into Camila's dark narco world. Camila enlists Teo, a high-powered lawyer, to help her with first big secretive move into taking over Epifanio's cartel. Meanwhile, Brenda, still on the run, finally makes contact with Teresa, who helps her escape, but not how she expected.
Teresa's first solo drug run is impacted by a deadly mistake; Brenda and Tony make an escape to Dallas.
After witnessing a horrific event, Teresa advances her plans; Brenda needs money to survive, and assembles a ragtag team of dealers.
In debt and short on supply, Camila grows desperate; Brenda's burgeoning drug enterprise creates a rift between her and Tony.
Camila sends Teresa out on a dangerous, but profitable midnight mission; Brenda puts her crew in the line of fire.
Desperate, Camila attempts a risky heist; Teresa goes undercover, and must make a choice that will forever change her.
Teresa races to save a witness; Camila assures her partners that she is back in business and done with Epifanio.
Camila returns to Mexico in order to protect her life; James hunts down Teresa; Teresa takes Maria through the tunnel to Mexico.
Camila's operation goes underground after aligning with the Jimenez cartel; Teresa and Brenda try to start a new life.
Teresa and Brenda risk everything through extortion; Camila takes steps to overtake Epifanio's empire.
Teresa risks her life to protect Güero's book; Camila's takeover hits a rough patch; Epifanio receives new intel.