J.D. flirts with the wife of a patient who's been in a coma for the past two years, whom they all call T.C.W. (Tasty Coma Wife). He feels guilty for doing that, even though she wants to go ahead with it.
Meanwhile, he can't stand listening to any more relationship problems, as everybody dumps their issues on his ears: Elliot, sabotaging her relationship with Paul over beef jerky, Carla, finding out her engagement ring passed through a patient's digestive system and Dr. Cox's unsucessful attempts to get some attention from Jordan, who can only think about her baby right now.
This half-hour comedy focuses on the bizarre experiences of fresh-faced medical intern John "J.D". Dorian as he embarks on his healing career in a surreal hospital crammed full of unpredictable staffers and patients - where humor and tragedy can merge paths at any time.
Joining the rumpled J.D. in his exhilarating brave new world are his college buddy, Chris Turk, an intern with a more elite surgical group, and J.D'.s fellow medical intern, the beautiful and driven Elliot Reid. Keeping the new interns on their toes are: the fatherly chief of medicine, Dr. Bob Kelso; the abrasive, worldly Dr. Perry Cox, and the caring but slightly jaded nurse Carla Espinosa. The hospital janitor also never seems to miss an opportunity to harass his target.