The new interns have to perform in the Sacred Heart traditional comedy show, so J.D. and Turk offer them to write the sketches. Meanwhile, the Janitor watches Carla in a delicate situation, and Elliot and her interns Sunny and Denise argue about a patient.
This half-hour comedy focuses on the bizarre experiences of fresh-faced medical intern John "J.D". Dorian as he embarks on his healing career in a surreal hospital crammed full of unpredictable staffers and patients - where humor and tragedy can merge paths at any time.
Joining the rumpled J.D. in his exhilarating brave new world are his college buddy, Chris Turk, an intern with a more elite surgical group, and J.D'.s fellow medical intern, the beautiful and driven Elliot Reid. Keeping the new interns on their toes are: the fatherly chief of medicine, Dr. Bob Kelso; the abrasive, worldly Dr. Perry Cox, and the caring but slightly jaded nurse Carla Espinosa. The hospital janitor also never seems to miss an opportunity to harass his target.