The Gallaghers adjust to life during the pandemic: Frank fears the loss of the South Side to gentrification, while bar closures force Kev and V to get creative at the Alibi. Sleep-deprived Lip and Tami work to make their new house a home as Carl finishes his time at the police academy. Debbie becomes her own boss and deals with the repercussions of her statutory rape conviction of 17-year-old Julia. Ian and Mickey's honeymoon phase is over as they have very different ideas about what married life would be.
It's Franny's birthday, and with Tami and Sandy's help, Debbie prepares to throw her the best princess party Franny never wanted. Ian is on the straight and narrow which forces Mickey to get a real job. Frank the weed connoisseur helps Kev and V with their struggling pot business. Lip's home renovations run him into some trouble with his new neighbors. Carl's first day on the force is not the vigilante fantasy he thought it would be. Liam profits from kids who find themselves in lunch debt due to a tyrannical lunch lady.
In a rush to get out of the house, Debbie loses track of Franny and has to balance her search for Franny with her handy-woman jobs. Meanwhile, Frank and Franny have a day of weed runs and adventure. Ian and Mickey question who is the "man" in their relationship. A delighted Carl gets a new Training Officer who loves to kick ass. When Brad and Cami learn about their newborn baby's health complications, Lip and Tami step in to help. Kev's newfound money and lack of modesty prove to be trouble.
The Milkoviches move in next door and wreak havoc, leading Frank, Kev and Liam to plot how to get rid of them. Mickey embarks on a new security gig for Kev and V and drags Ian along against his will. V and Debbie turn into stage moms when Gemma and Franny compete in the Little Miss South Side beauty pageant. Lip gets a big surprise when he reluctantly agrees to go to brunch with Tami and her old high school music teacher. When Carl's training officer is overly aggressive, Carl is forced to choose between his job and his neighborhood.
Ian and Mickey get creative when the safety of their security gig comes into question. Dynamic duo Frank and Kev make a last-ditch effort to take down the Milkovich's. V canvasses to get black people to the polls but realizes there's barely any black people left on the Southside. Lip and Tami get surprising news about their house that forces them to look elsewhere. Debbie takes Franny to a comic book signing for her favorite wrestler. Carl and Leesie's differing approaches to policing come to a head.
A surprising twist of fate has left the Milkovich's vulnerable, forcing Ian and Mickey to step in to help. Frank's day takes some unexpected turns and Liam deals with inner turmoil after doing a bad thing. Debbie confronts Sandy on their relationship, while Carl enjoys the spoils of his day off. Lip and Brad seek revenge on the new BornFree owners, all the while Lip is forced to figure out a plan for the future. While Kev runs the bar, V is class parent at school - but elementary school looks a little different these days.
The Gallaghers disagree on the fate of their childhood home so a stranded Frank tries to get back to weigh in on the matter. Realizing that they have none, Ian and Mickey embark on a journey to find gay friends. Carl is upset after his night with Tish, and Debbie and Sandy have another visitor from Sandy's past. Lip and Brad get ready to sell stolen bikes while Kevin has to think fast when he's spotted riding a stolen chopper. Veronica hopes to pass the rent control bill with Liam's help, but receives some unexpected news.
Frank and Liam compete in a renaming contest of the Dennis Hastert Middle School. Debbie has a day of zero responsibilities, while Ian and Mickey take on all the responsibility for Terry. Veronica is depressed about her mom moving so Kevin tries to cheer her up, all while planning a special surprise. Carl is put on vice squad, which is all fun and games, until it's not. Lip has a close encounter with the law, which forces Lip and Tami to team up and sends Brad into a spiral.
Frank wants to pull one last heist with the old gang. Debbie struggles with the idea of change and blames Lip, while Lip and Brad find out the new owners of BornFree are in the mob. Mickey and Ian learn a surprising truth about Terry's past, and Liam tries to find a new place to live. Veronica reluctantly helps her mom to Louisville, while Kevin is forced to watch Gemma and Amy while running the Alibi all on his own. Carl is put on the eviction unit and reunited with an old partner.
Lip has a million projects going on, and Frank is one of them. Liam is forced to watch Frank, so the two of them embark on a journey to take down Liam's classmate in an effort to get Liam into STEM school. Carl's disillusionment with the police forces comes to a head. Debbie embraces the next chapter of her life and hunts for a new place. Mickey and Ian toy with the idea of the West Side. Kev meets Veronica in Louisville in a last-ditch effort to convince Carol not to move.
Kev and V announce their big news. Lip has some promising leads on selling the house, forcing Debbie to reevaluate her future and her whole history of regrettable love interests. Ian and Mickey try to adjust to a vastly different life on the West Side. Carl's commitment to the force is challenged when he's reassigned to an unglamorous police unit. Liam reminds Frank of everything that makes Frank, Frank.
Ian and Mickey shop for furniture for their new place and Kev and V look for a buyer for the Alibi. While Lip settles for a new job, Carl finally finds his calling in a new role on the police force. Debbie plunges into a treacherous world when she meets someone new. Frank comes to terms with his own mortality. Series finale.