Twelve years in the future, Archer finds himself living in a modest home on a desolate planet with T'Pol as his caregiver. The last thing he remembers is walking down a corridor on his way to the Bridge. T'Pol explains that an anomaly hit the ship, and Archer knocked her out of the way of a distortion wave just in time. The wave rendered him unconscious, and when he awoke, Phlox had troubling news: Archer was infected with several clusters of parasites, which prevented him from forming long-term memories. Over the next few months, Phlox searched for a cure, but was unsuccessful - the organisms are from a domain outside of normal space-time, and none of his treatments had any effect. Meanwhile, T'Pol was granted a field commission and promoted to captain. After several months of searching, the crew learned where the Xindi weapon was being constructed - but the Xindi caught wind of it and sent ships to intercept Enterprise. The ensuing battle left Enterprise heavily damaged, and though the crew eventually located the facility where the weapon was being constructed, it had already been launched. Earth was destroyed. T'Pol relates to Archer that the Xindi also managed to destroy every human outpost they could find - only 6,000 humans are left.
Star Trek: Enterprise, a prequel set before the original series, follows the crew of Earth's first warp five starship. Lead by Jonathan Archer and his crew, the series follows their adventures as they explore never before seen parts of the galaxy, setting foot on new worlds and meeting new races, as well as some familiar ones.