With Butcher still missing, Hughie, Mother's Milk, Frenchie, and Kimiko are now fugitives, and Homelander and Vought are more powerful than ever. But just as the Boys are about to leave the country, they are pulled back into the fray.
Superpowered individuals are recognized as heroes by the general public but owned by powerful corporation Vought International, which markets and monetizes them. Outside of their heroic personas, most are arrogant and corrupt.
The Seven (Vought International's premier superhero team) are led by the egotistical and unstable Homelander, while the Boys (vigilantes looking to keep the corrupted heroes under control) are led by Billy Butcher, who despises all superpowered people. As a conflict ensues between the two groups, the series also follows the new members of each team: Hughie Campbell of the Boys, who joins the vigilantes after his girlfriend is killed by one of the Seven; and Annie January / Starlight of the Seven, a young and hopeful heroine forced to face the truth about the heroes she admires.