Dr. Thackery makes a move to return to The Knick, which the board frowns upon. Cornelia gets Cleary to do a dirty job, but it comes with a cost. Robertson makes a push for a new subway initiative. Barrow drives up construction costs. Lucy receives a surprise visitor from home.
The setting: downtown New York in 1900, a tumultuous time of massive change and great progress. The series centers around the groundbreaking surgeons, nurses and staff at Knickerbocker Hospital, who are pushing the bounds of medicine in a time of astonishingly high mortality rates and zero antibiotics.