Dave Johnson, the friendliest guy in the Midwest, moves his family to a neighborhood in Los Angeles where not everyone looks like him or appreciates his extreme neighborliness.
When a water pipe bursts at the Johnsons' home, Calvin reluctantly agrees to help Dave repair the damage. Also, Gemma discovers a surprising secret about her new neighbor, Tina.
Dave gives Calvin a spare key to the Johnsons' house in case of an emergency and is pleasantly surprised when the gesture is reciprocated - or so he thinks.
Dave and Gemma decide to invite the Butlers to their housewarming party. However, when everyone but Calvin accepts, Dave decides he's finally had enough of Calvin's refusal to welcome him to town.
Unexpected revelations are in the cards during the Johnsons' first game night together with the Butlers, when Gemma is prompted to rectify a past wrong and Malcolm makes a play for a fresh start with his father, Calvin.
Dave plans a special anniversary celebration for Gemma while Calvin and Tina babysit the Johnsons' son, Grover, during an evening when nothing goes according to plan.
When Dave drops by Calvin's longtime barbershop, he's quickly embraced by its owner and patrons, much to Calvin's consternation.
Dave and Gemma host a memorable Thanksgiving in their new home when Dave's politically incorrect mother, Paula, visits from out of town and meets Calvin, Tina and the rest of the Butler family for the first time.
When Calvin and Tina learn Marty has a new girlfriend, Chloe, they insist he invite her over for dinner, with surprising results.
When Malcolm is robbed and won't reveal the culprit, Calvin and Dave team up to crack the case of the missing sneakers. Also, Tina takes a unique approach to teaching Gemma self-defense.
Tina gets carried away when she tries to help Gemma ace her first fundraiser as school principal. Also, Dave aids Calvin in his efforts to win a special silent-auction prize for his mom.
When Dave and Gemma's elaborate plans for Grover's 7th birthday party go awry, Malcolm and Marty come to the rescue. Also, Calvin's choice of gift winds up sending one person to the hospital.
Calvin reluctantly invites Dave to join his guys' night at home with Malcolm and Marty, while Gemma and Tina take their first girls' trip to Vegas and find themselves unexpectedly in the spotlight.
Dave convinces Calvin to hold a yard sale, but when longtime neighborhood resident Miss Simpson makes a purchase Calvin quickly regrets, he enlists Dave to help him get the valuable object back.