After the crew saves a stranded ship and its attractive captain, Ed becomes smitten with the Orville's new guest, while Kelly suspects all is not what it seems. Meanwhile, Gordon attempts to teach Isaac the art of pulling off a practical joke.
Down on his luck after a bitter divorce, Planetary Union officer Ed Mercer finally gets his chance to command his own ship, the Orville, a not-so-top-of-the-line exploratory ship in Earth's interstellar Fleet.
Determined to prove his worth and start a new chapter, Ed discovers the first wrinkle in his plan when the First Officer assigned to his ship is his ex-wife, Kelly Grayson. As the new commander, Ed assembles a qualified - but eccentric - crew, including his best friend, Gordon, who has problems with authority but is the best helmsman in the fleet; Dr. Claire Finn; Bortus, an alien from a single-sex species; Isaac, an artificial life-form from a machine society; navigator John Lamarr; Alara Kitan, a young, inexperienced security officer; and Yaphit, a gelatinous creature.
Facing cosmic challenges from without and within, this motley crew of space explorers will boldly go where no comedic drama has gone before.