When the only way to stop Fanning and the virals' escape from Project NOAH involves a dangerous explosion that could leave Brad, Sykes, and the cure for the virus caught in the crossfire, Amy must be the one to decide what's best for humanity. In the wake of this, surprising alliances form and a key figure returns to instill confidence, convincing everyone to fight for their lives.
Project NOAH is a a secret medical facility, where scientists are experimenting with a dangerous virus that could lead to the cure for all disease, but also carries the potential to wipe out the human race. When a young girl, Amy Bellafonte, is chosen to be a test subject, Federal Agent Brad Wolgast is the man who is tasked with bringing her to Project NOAH. Ultimately, however, Wolgast becomes her surrogate father, trying to protect her at any cost.
Brad and Amy's journey will force them to confront Project NOAH's lead scientists, Major Nichole Sykes and Dr. Jonas Lwar, as well as the hardened former Navy Operative Clark Richards, whom Brad trained. It likewise brings them face-to-face with a dangerous new race of beings confined within the walls of Project NOAH and death-row inmates. In seeking out any allies he can find, Brad also turns to his former wife for help. But as Project NOAH's scientists hone in on a cure that could save humanity, these new beings begin to test their own powers, inching one step closer to an escape that could lead to an unimaginable apocalypse.