Andy tells a young pregnant woman whose had a heart attack, that in order for both her and her unborn child to be saved she'll need a heart transplant. However, the transplant is jeopardized due to unexpected complications with the donor's family.
An 18-year old in need of a double-lung transplant, struggles to survive as the team runs into an obstacle that may prevent her from being eligible for the procedure.
Andy battles UNOS (United Network for Organ Sharing) to allow a former drug addict to receive a new heart, but things become complicated when the patient disappears just before the surgery.
The parents of a football player killed in a bus crash must make a heartbreaking decision, whether to donate his organs or not. Meanwhile, Andy and Ryan scramble to find a procurement team so that a boy, desperately in need of a heart transplant can do so.
In order to save his life, Andy tries a risky new procedure on his wife's partner who suffers from an aortic aneurysm.
An 8-year-old boy bonds with Lisa who she saw being crushed by a ride at a fair. Andy and David try to get a patient some much needed medical attention.
Victor, a car crash victim insists he wants to be taken off the life support machine so that he can help others with his organs, while Andy and Sophia do all they can to save him.
A wealthy man attempts to buy his dying wife a new liver when she is denied a legal transplant. Andy gets a blast from the past when an old shows up at the hospital.
While Andy is forced to make the decision of whether he will allow a woman to begin a "daisy chain" and donate her kidney to a patient until an exact match is found for her husband, Andy has his suspicions that one of the recent patients are rejecting the new heart.
A firefighter has to deal with the hard choice of whether or not to be a living donor to her captain (who has mistreated her), while Andy's uncle shows up with a stab wound and requests him not to report the incident due to the fear it will violate his parole.
When Dr. Luc Bovell returns to Three Rivers, Andy is annoyed at his rival's status and popularity since he is rude to his patients.
Andy puts his patient Kuol at the top of the donor list to receive a new heart after his condition takes a turn for the worse. His transplant is put in jeopardy when police threaten to seize the money raised for Kuol's surgery.
When a bride is gunned down at her wedding, the team is sent to harvest her lungs to transplant but run into family problems. Meanwhile, a college basketball player about to turn pro is in need of a new heart.