When one of the world's most dangerous fugitives steals a state-of-the-art time machine, the U.S. government asks a history professor, Lucy Preston, a soldier, Wyatt Logan, and a scientist, Rufus Carlin, to embark on the adventure of a lifetime and chase the criminal mastermind, Garcia Flynn, to the Hindenburg disaster of 1937. While there, Lucy, Wyatt, and Rufus each have to draw on expertise to save the present and protect the past - possibly at great personal cost.
Lucy, Wyatt, and Rufus chase terrorist Garcia Flynn to the night of Lincoln's assassination, where they're horrified to learn that Flynn's linked up with history's most notorious assassin, John Wilkes Booth. Putting aside a tragedy of her own, Lucy speculates that Flynn intends to send the fragile nation into chaos by making a bad thing worse, and a debate rages among the team: should they alter history if it means changing it for the better?.
After landing in 1962 Las Vegas, Flynn has the team on the run with the era's most infamous mistress. During the restless, neon-lit night, Rufus meets his old mentor Anthony Bruhl, whose motives may be darker than anyone suspected. Meanwhile, Lucy's personal life is falling apart, Wyatt attempts to change history for himself, and we discover Flynn intends to gamble with far more human life than we realized.
Lucy, Wyatt, and Rufus are shocked when they're told the mothership has landed in Nazi Germany, but time is short, and they're the only ones equipped to hug Flynn and end his psychotic crusade. Now, in hot pursuit of a genius with sinister associations, the team weighs the consequences of Flynn's destruction, meets the man behind one of literature's most popular figures, and endures a very uncomfortable... party.
After one member's fired from the team, Flynn returns to a pivotal event in the war over Texas-the Battle of the Alamo. Our team finds themselves stranded inside the famous fort, surrounded by Mexican soldiers, knowing that everyone inside is fated to die. Now, with no hope of rescue and facing insurmountable odds, the trio of heroes learns the meaning of trust and sacrifice from people prepared to die for those around them.
The mystery behind the greatest political scandal of the 20th century is finally solved when Flynn beats our team to the punch in Richard Nixon's Washington. While Rufus and Lucy are set on an investigative course that leaves them both rattled to the core, Wyatt's tragic past erupts, and the secrecy behind Flynn's hidden agenda begins to unravel.
The team chases Garcia Flynn to 1754, but after he reveals his true intentions, they're forced to scramble through hostile territory. Now, if they want to survive, they'll need to learn to trust each other. Meanwhile, Agent Christopher quietly investigates Connor Mason, and Jiya has a hunch that Rufus might be resourceful enough to open a line of communication with the present.
As the nation waits to hear the fate of the astronauts of Apollo 11, Flynn arrives near mission control, intending to rewrite the events of that momentous day. Hot on his trail, Lucy, Wyatt, and Rufus need to be bolder than ever and call upon one of history's unsung heroes if they're going to have a shot at setting things right.
On the run with the bank-robbing Barrow gang, the team needs to gain the trust of ill-fated lovers Bonnie and Clyde in order to find out Flynn's target in the Depression-era South. While Agent Christopher tracks down a lead in present day, Lucy, Rufus, and Wyatt risk getting caught in the crossfire, suspecting that whatever Flynn's after may be a key piece of the whole puzzle.
A stunning turn during the American Revolution prompts Lucy, Wyatt, and Rufus to question whether they've been fighting on the wrong side this whole time. While Agent Christopher prepares for the worst back in present day, the team encounters the Father of the Country, makes a dubious pact, and confronts the possibility they may not be a trio for long.
Lucy's situation grows desperate after she's taken captive by Flynn and brought to the 1893 Chicago World's Fair. In their dogged pursuit of Lucy, Wyatt and Rufus fall into a sinister trap.
Flynn teams up with legendary outlaw, Jesse James. Together they cut a bloody swath across the American frontier. Hot on Flynn's trail, Lucy, Wyatt, and Rufus enlist the help of an iconic Marshal to help bring the fugitives to justice.
Wyatt convinces Rufus to steal the Lifeboat for an unauthorized mission to prevent Wyatt's wife's hugger from ever being born. Lucy must cover for them in the present, as Agent Christopher discovers the ship is missing and Anthony Bruhl makes an alarming confession.
As Lucy grapples with her newfound identity, Flynn disappears to 1927 France on the day that Charles Lindbergh completes his transatlantic flight. Now, Rufus, Lucy and their new soldier scramble through the City of Lights and team with young reporter, Ernest Hemingway, to keep history intact. Meanwhile, locked in an undisclosed location, a despondent Wyatt gets a visit from Agent Christopher, and the pair is left wondering if their enemies are closer than they realize.
Lucy, Wyatt, and Rufus decide to take matters into their own hands, but are caught off guard when Flynn lands in 1931 Chicago to call in a favor from notorious gangster Al Capone. Hot on Flynn's trail, our heroes try to enlist the help of famed lawman, Elliot Ness, in pursuit of Al Capone after Flynn aids him in avoiding justice. A clue leads the team to a crucial revelation about Rittenhouse.
With one of our heroes' lives on the line, the team chases Flynn to 1954 through the paranoid corridors of Joe McCarthy's Washington D.C., en route to a secret, once-a-generation meeting of Rittenhouse leaders. While there, Lucy must wager the ultimate sacrifice to save history as we know it.