In the days leading up to "The Rising", Vanessa is attacked and left for dead by an intruder. When Doc discovers anomalies in Vanessa's bloodwork, Axel and the marines come to retrieve the body, only to become marooned in the hospital when all hell breaks loose outside the building.
Vanessa Van Helsing, a descendant of Abraham Van Helsing, awakens from a coma after her supposed death to find herself in a post-apocalyptic world, three years after an eruption of the Yellowstone Caldera had blanketed the world in ash, blocking out sunlight and allowing vampires to overrun humanity. She is humanity's last hope, as her unique blood composition gives her the ability to turn vampires human. With this secret weapon, Vanessa becomes a prime target for the vampires. She has been protected by a Marine ordered to keep her safe, and the doctor who saved her, so she can lead a resistance against the vampires that plague the world's survivors.