The year is 2027, and the world has reached a tipping point: as the human population continues to dwindle due to the sterility problem, an equally devastating threat rises in the form of "the hybrids", an army of unstoppable lab-made creatures, hell-bent on destroying mankind.
Jackson and Logan discover a link between the hybrid attacks that occur in Portland and New York; Mitch is interrogated by a woman claiming to be his daughter, Clementine; and a new development in Abraham's research into the sterility crisis endangers his family.
Abraham and Dariela consider making a deal with Reiden Global for personal reasons, and Jamie and Clementine perform a risky surgery on Mitch.
Abraham and Dariela reunite with the team as they try and stop the hybrids from taking over New York City.
While Jamie's under arrest, she manages to manipulate Mitch and Logan into helping her hunt shepherds, members of a secretive group responsible for sterilizing humans.
Mitch seeks to rescue Clementine from her captors, and a glimpse into Jackson's sister Abigail's past reveals the origins of the hybrids.
The team sets out on a rescue mission for Abe and Dariela's son, Isaac. Then, in search of information on a new hybrid, Mitch and Jamie travel to California, where they cross paths with a familiar face from their past.
Abigail holds Jackson prisoner in order to extract information from him that is critical to her secret master plan, and the team faces a mid-air crisis when their plane experiences an electrical malfunction.
After Mitch's alter ego, Mr. Duncan, attacks the team's plane then flees, Jamie, Abe and Max set out to find him and help.
After Jackson attacks Abigail, the team rushes to save her as her life hangs in the balance.
As the team is trapped inside the plane by toxic spores surrounding them, complications arise during the delivery of Clementine's baby.
After the team's plane suffers a catastrophic accident in the hybrid zone, Dariela and Tessa set out on a rescue mission to save them.
The team races to stop the hybrids from breaching the barrier wall by shutting down the last beacon that draws them in.