When Jack casually gives Durbin some marriage advice, it backfires, gets Durbin kicked out of the house, and Jack takes him in. The A.P. Bio kids tell Jack if they can get Miles' DNA, they'll learn a little biology while pulling off the ultimate revenge.
When disgraced Harvard philosophy scholar Jack Griffin loses out on his dream job to his rival Miles Leonard, he is forced to return to Toledo, Ohio, and work as a high school Advanced Placement Biology teacher. As he comes crashing into Whitlock High School, Jack makes it absolutely clear he will not be teaching any biology.
Realizing he has a room full of honor roll students at his disposal, Jack decides instead to use the kids for his own benefit like getting revenge on Miles. Eager to prove that he is still king of the castle, Principal Durbin struggles to control the force of nature that is Jack Griffin.