"Are You There, Chelsea- is based on the book and comedian/talk show host Chelsea Handler. This show follows the adventures of Chelsea, a twenty-something woman who doesn't let anything stand in her way of succeeding in her life. With her friends, who know that it is Chelsea's way or else, Mark and Shoniqua are there to add support for their friend. However, Todd doesn't take Chelsea's attitude and keeps her mannerisms to a minimum.
Chelsea Handler, herself, makes a reoccurring appearance as Chelsea's sister, Sloan, a woman who is married and has a new baby. She and Chelsea share a commonality together, that is vodka.