As Wolf deals with a personal crisis that brings up dark corners from his past, the interns assist an MMA fighter exhibiting strange symptoms. Meanwhile, Pierce is visited by Bitsy, a gossipy Upper West Side housewife, who gives her some shocking intel about a nearby influential surgeon.

The doctors assist when a young professional looking for love on a reality dating show finds herself experiencing a mental health crisis while all eyes are on her. Wolf clashes with Frederick over his father's treatment.