After leaving Leo flat-lining at the end of the Christmas episode, April must deal with the outcome of the surgery. Facing her new reality, she must also face her first day back at work after being gone for four months. In remission and determined to move on with her life, her return reveals a new, young and ambitious boss at the paper who is ready to shake things up. But April's attempt to make a good impression may fall short when she botches her first assignment.
Meanwhile with an ideal marrow donor still to be found, Sara realizes it's time to reach out to the "other woman", Natalie's mother. Brenna eagerly anticipates Greer's return to school, but will she get the happy reunion she's been waiting for?
April is a smart aspiring journalist in her 20s who tries to balance her ambitious career with her family, which includes her widowed mom, rebellious little sister, and her grandmother. We meet April at a pivotal moment in her life: she's landed a fantastic opportunity to impress her hard-nosed Boston newspaper editor and an office romance with her super-sexy co-worker Dominic is just beginning to blossom. In an unexpected twist of fate, April lands in the hospital where her estranged uncle George works as an oncologist, and she learns the devastating news that she has cancer. The series follows April through her journey in the face of this daunting revelation, during a time in her life when the challenges of finding love and success would be enough to keep any girl occupied. But April is determined to fight and refuses to give up her dreams and goals.