Natalie finds out she is a half-match for April; but upon learning what the donation entails, she reconsiders going through with the procedure. Sara's attempts to change her mind only to bring up bitterness over the past. April has to re-earn her boss's trust after screwing up her last interview and reluctantly accepts a soft news assignment to help regain the paper's female readership.
Meanwhile, Brenna spends a surprising night out with Natalie, and Beth's relationship with Graham puts her in an awkward position with Dominic.
April is a smart aspiring journalist in her 20s who tries to balance her ambitious career with her family, which includes her widowed mom, rebellious little sister, and her grandmother. We meet April at a pivotal moment in her life: she's landed a fantastic opportunity to impress her hard-nosed Boston newspaper editor and an office romance with her super-sexy co-worker Dominic is just beginning to blossom. In an unexpected twist of fate, April lands in the hospital where her estranged uncle George works as an oncologist, and she learns the devastating news that she has cancer. The series follows April through her journey in the face of this daunting revelation, during a time in her life when the challenges of finding love and success would be enough to keep any girl occupied. But April is determined to fight and refuses to give up her dreams and goals.