Trying to avoid a confrontation with Brick, Zoe begins discreetly seeing patients in BlueBell again. But her plan goes awry when George informs her she has a non-compete clause in her contract that prevents her from practicing for a year in the town. Lavon is thrilled at the chance to bring a minor league baseball team to BlueBell, but needs Brick's help to woo the team's owner. Elsewhere, Lemon finds herself in hot water with the Belles after she tries to overthrow the current leader. Meanwhile, George finds himself needing medical attention during a tutoring session with Lynly, forcing him to call Zoe for help.
Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable - the other doctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meets Zoe. Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbor Wade Kinsella, and handsome lawyer George Tucker - who just happens to be Lemon's fiance. Zoe is out of her element and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself she hadn't known was there.