After a wild night out, a teenage girl is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction. Meanwhile, Cuddy, Wilson, and House spend a weekend away from the hospital to attend a medical conference, but things don't go as planned when House's private investigator, Lucas, returns.
As an infectious disease specialist, Dr. Gregory House is a brilliant diagnostician who loves the challenges of the medical puzzles he must solve in order to save lives. House solves the inexplicable cases that other doctors cannot understand.
House isn't alone in this quest. His team includes neurologist Dr. Eric Foreman, a neurologist with a troubled youth and a desire to avoid becoming as abrasive as House; immunologist Dr. Allison Cameron - who sometimes cares too much and has conflicting feelings about House; and Dr. Robert Chase, a specialist in intensive care who has lived a very privileged life. House's good (and possibly only) friend Dr. James Wilson is an oncology specialist, who has to help and stand up for House on a regular basis, while trying to get him to face a few harsh truths.
House must also deal with his boss, Lisa Cuddy who, while often opposing House's unconventional methods, must admit that he is the best doctor on her staff. When a patient's life hangs in the balance, House will do anything, including breaking the law, taking risks other doctors would not take, and sometimes even going as far as actually interacting with a patient. House's methods may be controversial but his results speak for themselves.
Inconsistencies with his team forced House to hire a new batch of doctors. This year House used an elimination process and the end resulted in hiring, Dr. Lawrence Kutner, Dr. Remy Hadley, and Dr. Christopher Taub. Although his old team no longer takes orders from House they're still around to throw in their professional knowledge when need is dire. Together they will continue to solve cases most doctors can't.