When the nuns surprise Jane by offering her a permanent teaching position, she's excited, but things become complicated when Rogelio offers Jane a writing internship at his telenovela. Alba encourages Xo to keep the promise she made to God about Rogelio. Meanwhile, Michael is convinced of Rafael's involvement with the mysterious Sin Rostro and disobeys his boss' direct order to leave Rafael alone.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.