When Rafael finally admits that he is over Jane, their co-parenting style is tested when they argue over what the best preschool is for Mateo. Xo is paranoid about Alba finding out her secret and what it will do to their relationship. Rogelio is ready to cross over to American TV, especially after he learns his nemesis is making the transition. Meanwhile, "Anezka" is trying to find new dirt on Rafael when she begins an unexpected romance.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.