When an asteroid is detected heading for Earth, Team Alien is put in charge of the rocket being sent to destroy it. Meanwhile, Dr. C sends B.O.B. to play hide and seek. Unfortunately, he winds up hiding in the fuel being used to power the rocket, and Team Monster must rescue B.O.B. and alter the rocket's trajectory so it'll actually hit its target.
Inspired by DreamWorks Animation's 2009 blockbuster feature film, this new series follows the further adventures of the beloved monsters- B.O.B., the gelatinous blob without a brain; Link, the prehistoric fish-man; Dr. Cockroach, the half-man/half-insect mad scientist; and Susan (aka Ginormica), the incredible growing woman-as they learn to adapt to a new world filled with bizarre aliens.