The local NCIS field office investigates criminal cases affecting military personnel in the Big Easy, a city known for its music, entertainment and decadence. Leading the team is Special Agent Dwayne Pride, aka 'King', a native of NOLA who is driven by his need to do what is right. Working with Pride is Special Agent Christopher LaSalle, who plays hard but works harder; and Special Agent Meredith 'Merri' Brody, a charismatic and tough interrogator who transferred from the Great Lakes office in search of a fresh start. Supporting them is coroner Dr. Loretta Wade, who is as eccentric as she is smart. This colorful city that harbors a dark side is a magnet for service personnel on leave, and when over-indulgence is followed by trouble, Pride's team is at its best.