Inspired by the oldest public hospital in America, this unique medical drama follows the brilliant and charming Dr. Max Goodwin, the institution's newest medical director who sets out to tear up the bureaucracy and provide exceptional care. How can he help? Well, the doctors and staff have heard this before. Not taking "no" for an answer, Dr. Goodwin must disrupt the status quo and prove he will stop at nothing to breathe new life into this understaffed, underfunded and underappreciated hospital - the only one in the world capable of treating Ebola patients, prisoners from Rikers and the President of the United States under one roof - and return it to the glory that put it on the map.
Max navigates his diagnosis while Dr. Sharpe encourages him to make a plan. Meanwhile, Dr. Bloom encourages Reynolds to take a chance and Dr. Kapoor and Iggy work together to help a child.
Reynolds begins to build his department as Dr. Sharpe battles skepticism from a patient's parents. Meanwhile, Max helps Bloom find a solution for a pregnant patient in a tough spot, all the while continuing to avoid the reality of his diagnosis.
When Max volunteers New Amsterdam to take over for a short-staffed hospital nearby, things get chaotic quickly. Iggy has a crisis of conscience after receiving the news that funding for a garden has been granted and an eager resident learns a secret about Dr. Bloom.
A journalist visits New Amsterdam to shadow Max and learn about the hospital. Bloom and Reynolds have a major disagreement after she makes a call against protocol and Kapoor deals with issues from his past.
The pressure is on as Max takes on his first annual fundraising gala at the hospital and emotions are high as some of the doctor's families join them for the event. Iggy struggles to break difficult news to his daughter and Bloom and Reynolds continue to deal with the fallout of their argument. Meanwhile, Kapoor and Dr. Sharpe work together to find out what is making a father and son duo so sick.
With a big domino transplant procedure on the line, Max must decide if he can be present in the hospital while also dealing with his illness. Meanwhile, a bond with a patient makes Bloom consider her personal life and Iggy makes progress on a long-standing case.
A patient's treatment plan takes an unexpected turn when Max gets overly invested. Meanwhile, Reynolds celebrates his birthday with some help from the hospital and Kapoor grapples with a case that hits close to home.
Max convinces Dr. Sharpe to take a risk on his course of treatment and Bloom grapples with a difficult conversation. Meanwhile, Dr. Kapoor considers helping his son in a big way after some advice from a friend.
As Max fights for his life, New Amsterdam is in full swing with a pertinent heart surgery that is not covered by insurance and a potential nurses walk out. As the team feels Max's absence and the doctors find out that they may have to treat one of their own, Sharpe must finally come clean about Max's condition.
As Max begins his treatment, he realizes that it may slow him down faster than he originally thought. Meanwhile, Reynolds must deal with an incident from his past when a reporter comes to the hospital and Sharpe and Bloom continue a contentious conversation.
Tensions are high in the hospital as Bloom is overruled on a diagnosis. Meanwhile, Iggy notices that something may be amiss with one of the hospital's most respected surgeons.
Max continues to work to solve underlying problems within the hospital despite his continuing struggles with treatment. Meanwhile, Reynolds makes the choice to do a costly surgery to determine an elusive diagnosis and Bloom must face her personal demons head-on.
Sharpe struggles when a case hits too close to home and Iggy uncovers a patient's surprising past. Meanwhile, Floyd makes progress in his personal life after some difficult news.
Max bonds with the patients undergoing chemo with him, but a conversation leads him to struggle with his reality. Meanwhile, Reynolds has difficulty handling a personal matter regarding a patient's family and Iggy struggles with a realization regarding his daughter.
When a history-making blizzard hits New York, Max and his staff must work together to keep their patients safe with little resources, even if it means taking to the streets of the city and braving the storm.
As the doctors continue to weather the storm without power, Max relies on an unlikely source to get the lights back on. Meanwhile, Reynolds must get creative as he continues to work to save Hugh with very few resources.
Reynolds struggles to help a young Cystic Fibrosis patient with curious symptoms while Kapoor finally comes face to face with Ella after their awkward encounter. Meanwhile, Sharpe takes a major step in her personal life.
When a NYPD officer is hit by a car in the line of duty, the hospital is turn upside down trying to save her. Meanwhile, Kapoor and Iggy work with a patient struggling with a previous surgery.
Max is forced to reckon with his diagnosis in a new way as things become more difficult for him. Meanwhile, Reynolds is forced to address what could have gone wrong in a recent surgery.
Max goes head-to-head with hospital administration when he comes up with a new plan for patients without insurance. Iggy struggles with an accusation brought against him. Sharpe navigates her role as deputy medical director.
Sharpe works on a creative way to help Max. Kapoor gets surprising news. Reynolds takes a big step in his relationship with Evie. one of the doctors makes a life-altering decision.