Dr. Geoffrey Pierce is an eccentric neuroscientist who uses his unique outlook and expertise to help the federal government crack difficult cases. Pierce's intimate knowledge of human behavior and masterful understanding of the mind are matched by his equally odd and imaginative view of the world.
FBI agent Kate Rossi is Pierce's former student and the person responsible for recruiting him to work for the government. Arjay Smith plays Max Lewicki, Pierce's teaching assistant who has spent nine years at college. Kelly Rowan is Natalie Vincent, Pierce's best friend and every bit his intellectual equal.