Sam and Dean discover the Alpha skinwalker's plan: create sleeper cells of his kind and turn them loose upon humanity. To find and stop the Alpha, the brothers need the help of a skinwalker that has taken the form of a dog and befriended its human family.
Season 6 Episode 8 of Supernatural resulted in a 0.00 rating in the 18-49 demographic.
s06e01 - Exile on Main Street
s06e02 - Two and a Half Men
s06e03 - The Third Man
s06e04 - Weekend at Bobby's
s06e05 - Live Free or Twihard
s06e06 - You Can't Handle the Truth
s06e07 - Family Matters
s06e08 - All Dogs Go to Heaven
s06e09 - Clap Your Hands If You Believe
s06e10 - Caged Heat
s06e11 - Apointment in Samarra
s06e12 - Like a Virgin
s06e13 - Unforgiven
s06e14 - Mannequin 3: The Reckoning
s06e15 - The French Mistake
s06e16 - And Then There Were None
s06e17 - My Heart Will Go On
s06e18 - Frontierland
s06e19 - Mommy Dearest
s06e20 - The Man Who Would Be King
s06e21 - Let It Bleed
s06e22 - The Man Who Knew Too Much
Sam Winchester is a college student bound for law school, determined to escape his family's past - unlike his older brother, Dean. Ever since they were little their father has been consumed with an obsession to find the evil forces that cuddled his beloved wife, and recruited his two young sons to help them. They have grown up as hunters of the supernatural. Sam escaped this way of life after high school, and now has a happy life with his girlfriend, Jessica, and a promising future career. Dean, however, stayed behind with his father to join him in his "hunting".
After Dean arrives for Sam's help when their father goes missing, Sam must join his brother to find him. His one weekend trip to search for the missing John Winchester becomes an ongoing quest after a horrible tragedy ruins any thought of a happy life for Sam.
The two brothers, bound by tragedy and blood to their mission, travel across the country encountering terrifying and dangerous forces most believe to be nothing but superstition and folklore, such as the Lady in White, the Indian beast known as the Wendigo, Phantom Travelers who cause plane crashes, Bloody Mary, and many more.