Dr. Murphy treats a patient who has an illness that is not only unpredictable in nature, but also unlike anything he or the team has seen before. Dr. Claire Brown continues to work through her grief, still reeling from Dr. Neil Melendez's death.

Dr. Shaun Murphy and the team try to get a better understanding of COVID-19; Claire looks for a way to grieve Melendez's death through her patients; Dr. Alex Park and Mia discuss their future together.