Will and Grace decide to intervene when they discover Grace's niece is dating a bisexual man. Jack gets permission from his husband to sleep with his celebrity hall pass. Karen struggles to adapt when her assistant books them on an economy flight.
The show takes place in New York City and focuses on Will Truman, a gay man and lawyer, and his best friend Grace Adler, a Jewish woman who runs her own interior design firm.
Also featured are their friends Karen Walker, a rich socialite, and Jack McFarland, a struggling actor/singer/dancer who also has had brief careers as an acting teacher, back-up dancer, cater-waiter, talk-show host and student nurse.