With Jennifer and Yorick reunited, Agent 355 pitches a plan for what comes next. The dead President's daughter, Kimberly, circles Jennifer's secret. Meanwhile, Nora Brady and her daughter Mack say goodbye to home.
In a post-apocalyptic world a mysterious cataclysmic event simultaneously killed every mammal with a Y chromosome but for one man, Yorick Brown, and his pet monkey Ampersand. The series follows Yorick as he traverses the new world, as its survivors struggle with their losses and attempt to restore world society - led by Yorick's mother, who is the new U.S. President Jennifer Brown.