Kenny becomes extremely depressed after his divorce is finalized. Frasier offers to refer him to another psychiatrist, but Kenny says that he would prefer to discuss his problems with Frasier. Frasier reluctantly agrees, but doesn't take any money. Frasier is thrilled about getting to work with a patient again, and quickly delves into Kenny's childhood issues and cites them as the source of his relationship problems. Kenny remains depressed, so Martin lets him tag along to McGinty's. They have a good time drinking and hanging out. Kenny decides to follow Martin's advice and start getting out of the house so that he can take his mind off his problems. He tells Frasier that he doesn't want to come in to see him anymore. Frasier is furious with Martin, and takes issue with his father's comments about psychiatry. However, Martin finally reminds him that Kenny is far from the only person with problems, and suggests that Frasier start treating patients again. Meanwhile, Niles and Daphne begin practicing yoga with an instructor who caters to Seattle's elite. Although he won't admit it, Niles grows jealous when Daphne proves to be much more flexible than he is.
After many years spent at the "Cheers" bar, Frasier moves back home to Seattle after his policeman father Martin Crane gets shot in the hip on duty. After Martin struggles with living alone after the incident, he moves in with Frasier in his luxury apartment at the Elliot Bay Towers along with his dog Eddie. Hired by Frasier, Daphne Moon also moves in as Martin's personal physiotherapist. Also living nearby is his younger brother Niles Crane, who is also a Psychiatrist.
Frasier's new life in Seattle beings when he is employed by a radio station to offer therapy in a call-in manner. Produced by Roz Doyle, who becomes Frasier's friend, Frasier handles the everyday problems or people... sometimes uninteresting and even frustrating to Frasier but his ultimate goal will stay the same he wants to and enjoys helping people.