Frasier and Niles open their own restaurant, "Les Frères Heureux" (The Happy Brothers). When Opening Night arrives, everything that can go wrong does.
After many years spent at the "Cheers" bar, Frasier moves back home to Seattle after his policeman father Martin Crane gets shot in the hip on duty. After Martin struggles with living alone after the incident, he moves in with Frasier in his luxury apartment at the Elliot Bay Towers along with his dog Eddie. Hired by Frasier, Daphne Moon also moves in as Martin's personal physiotherapist. Also living nearby is his younger brother Niles Crane, who is also a Psychiatrist.
Frasier's new life in Seattle beings when he is employed by a radio station to offer therapy in a call-in manner. Produced by Roz Doyle, who becomes Frasier's friend, Frasier handles the everyday problems or people... sometimes uninteresting and even frustrating to Frasier but his ultimate goal will stay the same he wants to and enjoys helping people.