In the surgical department of Holby City Hospital, surgeons Anton Meyer and Nick Jordan race against time to carry out a heart transplant operation, but first they have to make the difficult choice between two possible recipients, Alan Kenyon and Simon Harwood.
Nick Jordan is put to the test when he is the only cardio-thoracic surgeon available to perform an urgent operation.
Kirstie Collins, who is helping Muriel McKendrick with the trial of a new drug, finds a severe adverse reaction from a patient, and wants to alert the drugs company, but McKendrick warns her against doing so.
Kirstie Collins catches Nick Jordan in a compromising situation with Ellie Sharpe in a linen cupboard.
Nick Jordan has to assist Anton Meyer on a heart operation on a new-born baby, but he expresses his reservations to him.
Nick Jordan helps a family to make a difficult decision, but he can't escape a clash with Karen Newburn over their troubled past, as well as an altercation with an ex-boyfriend of Ellie Sharpe's.
The treatment of a young woman, Christine, causes conflict between Anton Meyer and Muriel McKendrick.
Sunny Sunderland enters a radio phone-in competition, winning a large sum of money - for charity.
Jasmine Hopkins is operated on by Nick Jordan, but hovers between life and death; it's discovered she's in the early stages of pregnancy.