When a defeated Kian finds himself in a dark place, will Jac be able to pull him back from the edge? Meanwhile, a past acquaintance puts Max in a compromising position.
Jac and Kian return to work, but can they support each other and conquer their demons? Demoted and back in the trenches, Serena must find a role for herself. And will Sacha's efforts to help with Essie's home life only push her into Ben's arms for good?
Serena needs to avoid causing trouble with an inspection looming, but when Jason has problems with the privatised porter company, she must decide if she can afford to help him. Nicky finds herself having to treat her own mother, who has been involved in a road accident, and is forced to take desperate measures to help her. Essie realises that she has to tell Ben everything about the illegal adoption if they are to stay together, but is not sure she can trust him with the truth.
On the 75th Holocaust Memorial Day, Sacha's great aunt, a survivor of the concentration camps, is admitted to hospital. Her health is deteriorating severely, and Sacha is devastated by the realisation that she i unlikely to live through the day. Cameron is suspicious of a stabbing victim's boyfriend, only to discover he is hiding injuries of his own. Nicky has to step in when her mother receives threatening phone calls after failing to pay her debts.
It's the day of Sacha's groundbreaking transplant operation. As he is still overcoming a bereavement, Max wonders whether Sacha is fit to carry out the procedure.
Cameron plans to give Chloe his mother's necklace as a Valentine's Day gift - but first he needs to get it back from Nicky. She has problems of her own - she's pawned Bernie's necklace to pay her mother's debts, but is still being harassed for more money, forcing her to put her life and career on the line. Sacha is troubled by a personal decision, but receives guidance from an old friend.
A reconciliation between Chloe and Cameron seems unlikely after the previous night's events, but nevertheless, he decides to make a bold move to win back her trust. A familiar face returns to Holby to perform surgery on Carole, and Dominic finds a much-needed source of moral support as he waits for the outcome. Jac makes plans for her first unsupervised visit from Emma, but things soon get out of control.
Ric is determined to do anything he can to help the relative of a former patient, despite the AAU being filled to capacity and the hospital being in the midst of a nursing crisis. Essie realises that she has to decide where she stands with Sasha when Ben makes a grand gesture. Kian returns from Holby from Canada to discover that Jac has been taking a step back from her work, and resolves to force her out of her comfort zone.
Max finds herself in a desolate state after receiving blind-siding news, Max tasks Jac and Kian to decide who should be Clinical Lead, but neither are quite ready to take on the baton, and a loved up Essie attempts to do the right thing, but her joy is short lived when shocking revelations threaten her friendship with Dom.
A hectic day sees Cameron seize his chance to impress. Reeling from recent revelations, Sacha, Essie, Dom and Ben face a life-saving surgery with a vulnerable child, and stressed by budget cuts, staffing shortages and an inflexible Max, worried Fletch begins to panic that Holby is heading for disaster.
Xavier is piecing together the puzzle of Evan's death and getting dangerously close to exposing the truth, Essie thinks the worst thing that will happen to her today is dealing with Children's Services, and Jac is keen to impress the Board with a complex and rare surgery that will put them ahead of the competition.
Max anxiously awaits a reunion with her estranged daughter, but Ric and Ange are concerned that she will not be able to juggle her work commitments with this important encounter. A new nurse joins Darwin, but Jac questions whether he has the specialist skills needed to carry out the role. Essie waits to discover whether her cancer has returned, while Sacha lets Dom in on a secret - he plans to propose.
Max is tempted to start drinking again after meeting her daughter. Although she manages to resist, she still raises suspicions among her colleagues that she has relapsed, and is accused of being unfit to perform surgery. David is determined to prove his worth, and joins Fletch in making a complaint against the nurses being moved around the hospital. Essie keeps her news from Sacha, which puts Dom in the awkward position of having to life for her.
As his disciplinary hearing begins, Xav is determined to prove that Cameron killed Evan. Essie faces the fight of her life as she undergoes her first round of chemotherapy.
Essie's friends try to keep things normal as she continues her chemotherapy. Jac and Kian's relationship takes an unexpected turn, and can Guy keep his relationship under wraps?
Essie puts on a brave face, but the effects of chemo start to take a toll. Guy has a lot to prove as he faces a challenging case on his first day on AAU, and Jac tries to keep things professional with Kian on the ward, but he has other ideas.
As things with Jac heat up, Kian is thrown off balance when a patient causes painful memories to resurface. Tensions run high as Louis adjusts to life in his mum's hospital, and Guy tries to make amends for last week. Fletch puts his foot in it when he receives an unwanted gift.
Fletch and his daughter Evie reveal life-changing secrets they have both been keeping, and what will Max do when dangerous truths are exposed on the biggest day of her career?
Cameron is gutted when his performance review doesn't go to plan, and Nicky's attempts to find a life-saving treatment for Brenda put her at odds with Jac. While staff fuss over Fletch as he recovers from surgery, Essie may know something that will change life on Keller forever.
Nicky is stressed and exhausted, with devastating consequences at work. As she struggles to cope with the pressure from her mother, a tragic incident pushes her over the edge. Ange tells Cameron he is not ready to take the next step in his career. Frustrated by the rejection, he takes out his anger on Louis. Sacha decides to respect Essie's wishes concerning her cancer treatment, but Dominic urges him to persuade her not to give up on palliative care.
Nicky must confront her fears, Fletch and Essie try to remain upbeat, and Guy is determined to prove he's still a top surgeon.
Kian returns to Holby, determined to make amends with Jac. Essie searches for answers, and Ric sets out on a personal vendetta.
Cameron fears new locum Drew is out to expose him, Kian spends the day babysitting Emma in order to win back Jac's heart, and how low will Sacha stoop to convince Essie?
Ric clashes with Max when his determination to destroy Guy puts his health at risk. Distressed by Frankie's disappearance, Essie's suspicions are raised when Sacha avoids the subject. Chloe struggles to keep things professional when her dating life spills onto the ward.
Finding Ric unconscious in theatre, Guy capitalises on the unexpected opportunity. Sacha tries to make things right with Essie, and Nicky receives a surprising offer.
Rick wakes up from his coma to find the world is in the middle of a COVID 19 pandemic.
Jac rushes in a mystery patient, whose arrival sets in motion in a deepening medical crisis that could have serious repercussions for her secret relationship with Kian. Keller is shocked when a new member of staff reveals the truth about Sacha's deception, and is tempted to take out his anguish on a vulnerable patient. Cameron basks in the glory of being declared a hero - prompting Nicky to issue him with an ultimatum.
Max wrestles with the after-effects of neurosurgery and the financial pressure on the hospital, but things get worse when an encounter with an old enemy puts a strain on her relationship with Louis. Kian brings in some new recruits to help solve Jac's medical mystery, and a new arrival stirs up unpleasant memories for Donna.
Sacha battles against the odds to keep going after Essie's death. Cameron tries to win Chloe over, with dramatic consequences. Kian finds himself in a compromised position when Clayton calls him out.
Chloe and Cameron become completely estranged when she finds out that they are competing for the same job. Sacha and Jodie continue to stick together against the naysayers.
Kian's cold turkey is tested when Sarah Jane calls in a favour. Can Kian stand firm, or will he crack under the pressure?
Sacha buries his head in the sand when Beka is taken ill on New Year's Eve. Will he figure out the truth before it's too late?
Skylar's mistake has fatal consequences, but is she really the one to blame? Kian admits his addiction to Jac, and Donna tries to put Xavier's memory to rest.
It's the day of the hearing, but who will the panel listen to, Cameron or Skylar? Jac can't shake her worries about what Kian is getting up to.
A returning patient wreaks havoc for Jac, and Sacha fears for his daughter while Jodie is on the loose.
The hospital is locked down with a gunman on the loose. Trapped in theatre, Cameron needs Nicky's help if he is not to be exposed as being way out of his depth.
Sacha gets the shock of his life when Jodie appears back on the scene. On her first day on Darwin, Jac's replacement, Sahira Shah, doesn't take kindly to Kian. And a bubbly new nurse, Kylie, arrives in acute admissions, but will she survive her first day?
Sacha and Hanssen battle to save Dom's life in theatre, while Jodie is terrified that she might lose her baby. Sahira tries to steady the good ship Holby, up on Darwin.
Ange blocks Dom's discharge, Alex makes a shocking discovery when a patient arouses his suspicions, and Nicky's health issues return.
Hanssen is shaken when a figure from his past appears. Cameron is backed into a corner when Bobby arrives on the ward threatening to talk. Ange and Dom clash over his decision to sue the hospital.
Chloe is suspended, unable to explain why one of her patients died - and as she leaves she confides her suspicion to Ange that Cameron was involved in the patient's death. Sahira considers bumping her father up the transplant list and on Lucky's last day she pulls out all the stops to help a patient with a phobia of hospitals. Will it be enough for Max to keep the psychiatric nurse on at Holby?
After learning from Sahira that he may not have been Reyhan's only victim, a distracted Hanssen makes a terrible mistake in theatre. Will it be life-ending for Reyhan?
Cameron holds Ange hostage as the truth of his crimes comes to light. Max needs to look out for Louis, but is she up to it? And Dom is back on the ward for the first time since he decided to sue the hospital.
Reyhan challenges Hanssen to tell Sahira the truth, Nicky vents her frustrations on a shady patient, and the team rally to support Ange after her ordeal with Cameron.