Mo is knocked for six when her old friend Sorcia turns up with Mo's surrogate son, William. Sublimating her distress over the break-up of her marriage, Cara defies Raf to help a vulnerable patient. Jesse strives to prove himself as a surgeon when he shadows Sacha for the day.
When Nicole Brady is admitted Cara is put in a difficult position as her husband's lover gives birth on AAU. But when Nicole's husband, Sean, realises the baby isn't his, Cara is compelled to take drastic action.
In the aftermath of his hostage ordeal, Guy wants to avoid the stress of surgery but finds himself with a comically morbid patient who needs his expertise. Will he be able to hold his nerve in theatre?
Still in shock after the tragic death of her friend Sorcia, Mo is focused on caring for her surrogate son William. Her Holby family, Ollie and Zosia rally round. But can they persuade her to take a break from parenting duties?.
Cara turns to Jed for help when she finds herself having to answer awkward questions about Nicole's disappearance. But, unable to face the truth about her troubled ex, Cara finds her lies ultimately lead an innocent Raf into danger.
Arthur returns to the hospital, but it is clear he has a long road to convince Serena that he can function on the ward and to repair his friendship with Morven. Ollie does some well meaning interfering for Zosia, but ends up doing more bad than good. Guy is struggling with a crisis of confidence, and this isn't helped when Patsy Brassvines son is admitted with a serious neurological condition that very few surgeons with look at. When no-one else is available, Guy has to confront his daemons to and save the patients life.
Mo is feeling positive, as it is time to return William to Brett. However when there is a setback and Brett has second thoughts when Sorcia's mother is called in, who insists that Mo no longer sees William. Mo feels she needs William, and runs away with him. Sacha is finally being interviewed for the post of Consultant General Surgeon, but when he finds out Patsy Brassvine coerced his patient into having keyhole instead of open surgery, resulting in complications and two further operations, Sacha makes it clear to Hanssen and the board that his patient care will always come above any promotion. Serena has a rather difficult day on AAU, when her ex-husband Edward invites her to his wedding, and she has to deal with a hysterical Arthur who has a toy soldier stuck in his arm.
When she discovers her husband Jed abandoned Nicole Brady after the birth of their baby, Cara is determined to find out why.
Dom and Jesse compete for a difficult case, but Dom gets more than he bargained for when he develops feelings for the patient.
With an absent baby William still on her mind, Mo takes a risk with her future when an unexpected patient arrives on Darwin.
The formidable Jac Naylor is back on Darwin and Ollie is intent on not letting her belittle him any more.
Morven gets drawn into an elderly couple's emotional case, despite her unwavering professionalism.
Dom's torn as he struggles to read his patient's motives, as he finds himself falling in love.
Arthur pulls out all the stops to help a grieving patient and save his friendship with Morven.
Zosia's future on Darwin is threatened under Jac's new regime. Can she fight to save her position?
Head over heels, Dom lays his heart on the line for a patient he's fallen for.
Jesse is forced to relive tragic events when he treats the seriously ill sister of a former patient. Sparks fly as Fran and Jac clash over the treatment of a patient. Fletch and Raf play cupid with Cara.
Fran ramps up her manoeuvres against Jac, and when she raises the possibility of a formal complaint from a patient's sister, Hanssen has to take her concerns seriously. But has Fran underestimated Jac's ability to fight back? Serena's disappointed when her daughter bails out of their planned Christmas together. Raf and Fletch are also dreading the festivities, but perhaps Serena has the perfect solution? In the first flush of love, Dominic's keen to buy the perfect Christmas present for Lee with the help of a willing patient. However, a shocking revelation leaves him reeling.
Troubled nurse Fran returns to Holby and takes drastic action to get Jac's attention. She finally reveals her true identity and the terrible childhood secret she shares with Jac. But tragedy strikes and a life is left hanging in the balance. Sacha finds himself having to treat the man who bullied him at school. It is a difficult case and a crisis of confidence ensues, as Sacha slips back into the role of victim. But an unlikely ally helps Sacha appreciate his worth and encourages him to step forward for the consultant position. Christmas romance is in the air. When a difficult patient steps out of line and Arthur wades in to defend Morven, her heart is set aflutter. Ollie and Zosia resolve to put their unhappy Christmases behind them, getting caught up in the romance when they help a patient propose to his girlfriend.
Serena's all set to spend another New Year's Eve alone. But, when revellers at a gig are attacked, fate brings more than just a few casualties onto AAU. Serena's ex-flame Robbie comes storming back into her life, forcing her to reassess her future. Ric Griffin returns to Holby City, only to discover big changes have been made. Ric finds himself feeling like an outsider, and his insecurity leads to bad judgement, but he finds an unlikely ally in Adele, who sets him straight. Happy with her decision to have a baby alone, Mo finds herself facing a tough choice when Mr T suggests himself as perfect sperm donor material.
Arthur is pushed to the limit when he tries to win Morven's affections.
Zosia is offered a prestigious research internship in Edinburgh, but how does Ollie feel about this?
Hanssen sends Dom, Morven and Arthur to an outdoor pursuit centre to battle for a research grant, but the competition gets a whole lot harder when it becomes clear that Morven's father is involved. Does Arthur have what it takes to prove himself?
Zosia is torn when Jac offers her a research internship in Edinburgh. Can Ollie finally be honest about his feelings for her and can he make her stay?.
Guy's career continues to go from strength to strength but there is a cost. Essie lets her personal life affect her professional one as she attempts to deal with a difficult mother and son relationship.
Hanssen gets ready to fly back to Sweden to see his family and becomes suspicious that Guy is attempting to wrest control of the hospital something which Guy later publicly announces. Serena looks for reassurance that Hanssen will stay and fight the battle.
It's Arthur's first day back on Keller, but how will he cope when his first patient is Morven's dad?
Mo and Mr T are forced to face their feelings for each other when Mo finds out if she's pregnant.
A shocking family secret is revealed when a patient on AAU opens up old wounds for Serena.
When an army medic arrives on Darwin, tensions run high for Guy and Ollie.
Serena battles with a difficult decision after the discovery of a family secret.
Dom lands himself in hot water when he tries to keep a secret from Ric.
A figure from Dominic's past makes an unwelcome return, with traumatic consequences. The death of Serena's sister sets off a chain of events that brings an unexpected visitor to Holby. Zosia, over-involved in the personal life of her patient, Major Bernie Wolfe, finds herself out of her depth.
It's Dom's first day back at work after Lee's attack. He's been cleared of any wrong-doing by the police but is stunned that he's now the focus of an internal investigation based on a complaint made by Lee. He's emerged unscathed from the assault but does Lee still have the power to hurt him professionally? When tests reveal that Austin's liver disease has progressed, Morven takes decisive action to help her father. Arthur, however, is alarmed. Is Morven is taking unnecessary risks with her own health? Mo needs to take her plans for solo parenthood to the next stage and find a suitable baby father. However, she distracts herself helping a patient. Just how committed is she to having a baby, now Mr T is out of the picture?.
Bernie starts her first day on the ward trying to put her army life behind her as Arthur's dream of becoming a life donor gets a set back as Serena has to make a decision regarding Jason.
Arthur goes into battle for a young patient who was hit by a train, but buries his head in the sand over his own health. A hungover Adele gets more than she bargains for when she becomes Guy Self's nurse for the day. Morven arranges a charity auction and Fletch sells Raf to the highest bidder!.
Ric battles to stay in control when operating on his much-loved old school teacher, while a feisty young patient reminds him of his younger self. Mo is left reeling when she finds out she didn't get the consultant's job and realises that it's gone to an old acquaintance of Jac's. Serena is head over heels in love with Robbie but feels nervous about introducing him to her family.
Bernie ends up having to question what she wants after her future at the hospital is put in doubt. Ollie and Zosia's world is blown apart after a former flame of his shows up.
Morven is left reeling by a life changing birthday gift as Mo clashes with Sir Dennis over a patient as Ric suffers an emotional outburst.
When Cara makes a move on Raf, complications arise as Arthur receives some shattering news as an old friend of Adele's is admitted to Darwin.
Jason shows up on AAU with his seriously ill carer Allan and Serena's personal involvement manages to affect her professional judgement as Dom tries to support Arthur following the news that his cancer has spread as Cara has her first day on Darwin.
Following the death of his mother, Jesse attempts to reappraise his relationship with his father as Ina is readmitted to Darwin.
Bernie has to work alongside an old army colleague and ends up being forced to confront the secrets of the past and face the truth behind her sudden exit from the army as Mr T learns that no one takes him seriously as Serena has a choice to make between her happiness and Jason.
Bernie finds herself being served with divorce papers as Austin is admitted in urgent need of a transplant as Zosia persuades a dying patient to act as a guinea pig.
The arrival of her ex sees Bernie trying to keep her secret hidden as the hospital's new psychiatrist Naomi Palmer makes an instant impression on Fletch.
Mo finds herself having to listen to her heart instead of her head as Serena's actions leave devastating consequences as Arthur and Morven have a day they won't forget.
Zosia manages to overstep the mark and accuses a patient of a media leak forcing Oliver to deal with an unwelcome dilemma. Zosia comes to a gut-wrenching decision as Serena discovers Bernie is working on AAU, Dominic has to face his fears.
Arthur is determined to proof himself with Hanssen's ambitions as Raf manages to see Naomi in a different light as Oliver tries to get back together with Zosia.
Zosia finds herself having to chose between Arthur and her career as Dom finds his loyalty being tested by a familiar face as Bernie finds it hard to find her place on AAU.
Zosia begins to question where her loyalties lie as Arthur and Morven have a decision to make as Dom battles his guilt.
A major train accident sees Dom with the perfect opportunity to escape back into work mode. Bernie's husband attempts to to play dirty in the divorce, as he turns her children against her.
As Jac launches the fully-formed Digby Stent, it looks like that someone has stolen their patent. Dom's first day back doesn't go as planned after a forthright new registrar shakes up the ward.
Dominic comes up with a unique way to grieve the loss of his best friend. Raf and Fletch clash after Raf reveals how he really feels about Naomi.
An allergic reaction leaves Jac unable to operate and having to rely on Oliver as Essie is going full speed in a bid to get pregnant as Raf and Fletch have their relationship tested over Naomi.
Mo finds it hard to cope as she struggles with her pregnancy as Fletch gets more than he bargained for when Mikey bonds with a drug addict patient as Isaac aims to impress Ric.
Bernie's absence leaves Serena struggling to manage the new trauma unit as Jasmine Burrows starts her first shift on Darwin as Essie attempts to track down a patient who goes missing.
When he is contacted by Elliot about a job in Pakistan, Ollie begins to question his place at Holby. After he clashes on another case with Guy, and Mo refuses to back him up, Ollie decides enough is enough.
Morven returns to work and is surprised when Hugh Musgrove, a former patient of hers and Arthur's, arrives. Morven struggles to treat Hugh's new wife, having treated his wife Beth before she passed away, but a reminder from Arthur helps her regain her strength as a doctor.
Always unlucky in love, Dom is reluctant to accept an invitation to a formal ball from Isaac. Essie encourages Dom not to let his past experiences hold him back with Isaac, who Dom finds hard to resist.
Ric is perturbed when the hospital's memorial for Arthur proves inadequate. Tasked with finding a more fitting alternative, Ric's unresolved grief comes to the fore. Will it have a negative impact on how he treats his current patient? Will he fail to save yet another young man?
When long-term Herzig patient Lexy is readmitted, Oliver is at pains to diagnose the problem. In turn, Lexy diagnoses his own romantic malaise, recommending he move on romantically from Zosia.
With Jason on the ward for a day in his capacity as clinical audit assistant, Serena is keen to keep a watchful eye on him. However, it's a shock when she finds herself under the professional microscope. Will she be found wanting?
Bernie's son Cameron comes crashing into the hospital, forcing Bernie to face some home truths about her poor parenting. When Cameron then asks Bernie to lie for him about a serious car accident, she finds it harder than ever to refuse him.
Buoyed by the launch of his memoir and the speech to investors, Guy is brought crashing down to earth when someone from his past turns up and reopens old wounds.
Jac returns from a break and learns that Guy's mother is on her ward and needs urgent treatment. Realising that all is not well between mother and son, she can't help but hold a grudge against Guy. She's impressed by young junior doctor Jasmine, who shows a keen interest in the medicine, but that soon turns sour when Jac discovers the truth about her.
With Evie still recovering from her fall, Fletch commits to being a better dad.
Sacha's birthday celebrations don't go quite according to plan.
Fletch is recovering from being attacked. Progress stalls when he loses feeling in his feet. As the paralysis spreads, Raf struggles to diagnose the cause. Will he make a breakthrough before it is too late?
The passionate courtship of a patient and her beau reminds Zosia what she has lost with Ollie. In the dark about Ollie's relationship with Jasmine, Zosia begins to think about the possibility of reconciliation.
A happily engaged patient and her partner present a vision of what might have been for Sacha and Essie. Have they made the right decision in breaking up?.
Dominic is perturbed when Isaac's former surgical mentor is admitted. Despite the existence of a wife, it's clear there's a personal connection between the two men. Is Dom prepared to accept Isaac's past?
Jasmine is keen to impress Jac professionally and make a connection with her half-sister personally. But will Jac's public acknowledgement of their relationship bring them together or drive them further apart?
Ric is dispatched by Hanssen to deal with the estranged wife of the local MP - the feisty, French Francoise. Will Ric allow himself to succumb to her Gallic charms?
Mr T comes to Mo's rescue when she fears for her baby's life. Bernie makes a big decision about her future with Serena when an exciting opportunity arises. A big step in his relationship with Isaac puts Dom's friendship with Zosia at risk.
An accident in rehab sets back Fletch's recovery, but it's his attitude that proves the biggest obstacle. Can he beat the doom and gloom before pushing away those who are trying to help him?
Isaac wants to impress Ric and Dom wants to impress Isaac, but when Dom sidelines his own success to help make Isaac look good they both wind up in trouble.
Mo tries to befriend Inga in light of her new role as best man. Her attempts prove futile when she puts her foot in her mouth repeatedly and winds up covered in wee, having made an enemy out of Inga instead.