asmine gets herself into trouble as she battles her hangover while working with Ric. Things take a turn for the worse when she finds comfort speaking to Tristan Wood, using him as her confidant.
Zosia's behaviour continues to spiral out of control leading Jac to become concerned for her. Morven faces her fears when she takes charge of a charming patient.
Ric has been suspended and Tristan is on the prowl. An ever watchful Hanssen pays a heavy price when he takes Jasmine under his wing. When Ollie doubts a patient's credibility and questions Zosia's judgment, the ex-lovers clash. Determined to protect Zosia at any cost, Ollie is blown away by a startling revelation. Aware that she is subject of gossip and struggling to manage her feelings for Bernie, Serena is unprepared for what unfolds on AAU.
After saving a life in a near-death trauma case, an overconfident Morven clashes with Raf when he is not convinced that her motives are purely professionally.
When Tristan asks Guy for a personal favour, Zosia warns Guy that Tristan is not to be trusted. But Guy strikes a deal with Tristan and his reputation hangs in the balance.
When his living habits are called into question, a determined Dominic fights to prove his worth to Isaac but is unprepared for the consequences of his actions.
Part one of two. Guy's plans for his much anticipated Neurosurgical Unit are put in jeopardy when he makes a shocking discovery about Tristan Wood - the Unit's main benefactor. Meanwhile, Serena considers re-kindling her romance with a smitten Robbie but, with Bernie in her thoughts, can she commit to happy ever after with him? And Ric is pressurised to undermine everything he's worked for by Tristan.
Part two of two. A conflicted Guy fights to save Tristan's life, and Raf's budding relationship with Kim is tested when he makes a shocking discovery. Meanwhile, spurred by evidence of Essie's romantic conquests, Sacha tries online dating, but is it really a good match for him?.
Dom stoops to low levels to land an assistant's position after Isaac gets a research grant. Elsewhere, Inga fights for her fiancé attention, and Bernie returns.
Matteo's arrival irritates Jac and when the medic discovers his past misdemeanours, she throws down the gauntlet. Elsewhere, Dominic gets emotionally embroiled in a challenging case.
Jac puts her patient before her own health concerns, with serious consequences. Elsewhere Raf is taken aback when Parker is brought into hospital and is concerned about the boy's welfare.
When Kim gets positive news regarding her kidney treatment, Essie must deal with the imminent departure of Parker, who has been staying with her. Desperate not to lose him, Essie takes decisive action only for a sympathetic Sacha to try and talk her round.
A terrifying blast from the past upsets Dom's plans for the perfect Christmas with Isaac, while Jac pushes her closest friend away as she waits on some Life changing news.
Mo strives to suppress her true feelings for Mr T, Jasmine is given her last chance on the Acute Assessment Unit, while Essie and Raf comes to blows after a difficult patient.
When Mo uncovers a secret, Mr T and Inga's Swedish-Style wedding takes a dark turn, While Serena, Elinor and Jason are involved in a car accident.
Oliver must compete for both funding and Jac's support when Matteo pitches a tempting rival project, and Dominic tries to keep his relationship with Isaac a secret from his parents.
Sacha becomes suspicious about Essie and Raf's relationship, and Fletch fights to save his friend Artem's life when the old gambler returns to the Acute Assessment Unit (AAU).
Mo returns from maternity leave and drops a bombshell, while Dominic gets a shock when he realises that going to Hawaii with Isaac is not going to be as straightforward as he hoped.
A grief-striker Derena returns to work looking for answers and Dominic is in turmoil when Isaac reveals a devastating betrayal. Meanwhile, Ollie and Zosia question if they are ready for the next stage in their relationships.
A familiar face makes a return under shocking circumstances, and grief-stricken Serena takes an eager Jasmine under her wing, but both get more than they bargained for.
Jac may finally acknowledge her feelings for Matteo, and Bernie sees through Serena's attempts to keep everything normal.
Isaac's dark side comes to surface as his relationship with Dom reaches breaking point, and Serena's mentoring of Jasmine gives Morven cause for concern.
Raf enthusiastically makes plans for the future with Kim and the twins he is to be a father of. However, his hopes and dreams looks set to be dashed by a series of revelations.
Jasmine fights chronic fatigue while trying to impress Serena, Essie wants to become Parker's foster mother, and Oliver tries to maintain his new zen outlook when rivals Jac and Matteo receive project funding.
Dominic's trust in Issac is rocked when a patient they both know is abandoned at the hospital having overdosed, and Fletch makes a shocking discovery about the man Morven has been messaging.
Essie is shocked when Parker turns up with a friend, while Zosia is harbouring a secret from Ollie and is horrified to learn that Isaac knows what it is.
Isaac lashes out when Dom questions their relationship, Serena is dealt a further blow after Elinor's death, and a drunken mistake prompts Ollie to take a big step in his relationship with Zosia.
Serena faces her demons and comes to a heart-wrenching conclusion, Zosia takes action when Issac reveals his true colours, and Mo risks her professional reputation.
Dominic and Isaac's toxic relationship finally reaches boiling point, Fletch's world is shattered by a life-changing revelation, while Matteo tries to reunite Jac and Jasmine.
Jac and Matteo's relationship seem to be heading in the right direction, but when she becomes suspicious of his motives, her investigation unearth skeletons in his closet.
Matteo and Jac clash over the patient, Sacha Tries to keep a secret from Essie, and Ric cracks the whip on the Acute Assessment Unit Floor, But a surprise visitor throws him off his game.
Mo finds herself caught between pregnant patient Trixie and Derwoods mother, Oliver's eagerness to impress causes friction between Bernie and Ric, While Sacha revisits his own childhood when his first girlfriend is admitted.
Matteo wants to prove his marriage is over, but a face from the past brings up painful memories of his life before Holby. Meanwhile, Dominic struggles with his first day back on Keller when a deceitful patient reminds him of his traumatic relationship with Isaac. And when Bernie's son Cameron returns, Morven must finally confront her feelings for him.
Jac's job and livelihood are at risk when a mystery patient arrives on Darwin and seeks help, while Keller welcomes a new face to the team. Elsewhere, Oliver has his mind preoccupied with a surprise from Zosia.
Lofty is unexpectedly confronted with his past and realises that he has to come to terms with the life changing choices he has made, while Mo is ecstatic to be offered Jac's job.
As a personal emergency strikes, Mo Makes a heart-wrenching decision, and when Nina oversteps the mark with a patient on AAU, her judgement is called into question.
Dominic and Sacha clash professionally, and with Jac and Jasmine at odds, Fran makes it her business to reunite them - with unsettling consequences,
It's crunch time for Mo, who has some difficult life choices to make, and a patient who is dear to Ric forces him to try to mend broken ties. Meanwhile Jasmine has growing suspicious of Fran's intensions with Jac.
As Jasmine begins to investigate the past, She makes a shocking discovery, while a misunderstanding leaves a vulnerable Dom at odds with his new friend Lofty.
Jac buries herself in work, determined to save he life of a scared patient, while Sacha is forced to confront his faith when his mother sets him up on a blind date.
A grieving Morven will not accept the circumstances of a close tragedy, while a familiar face arrives on Keller for emergency surgery, putting Sacha in a compromising position.
Jac and Fran get the shock of their lives when someone from their past turns up at the hospital while Raf realises that he likes Essie more than he's letting on.
Essie worries that she is not being a good foster parent to Parker, and a tricky patient diagnosis throws Morven straight in at the deep end on her first day back.
Donna is dealt a cruel blow by her ex, but assistance is on hand from a surprising source. Elsewhere Dominic wants to uncover the truth about Lofty's life, but he is not ready for what unfolds.
Nina strikes a deal with a face from her past, party animal Morven makes a regretful decision, and Sacha struggles with the new woman in his life.
Bernie is confronted with an impossible situation, Ollie and Zosia are made an offer they cannot refuse, and Lofty has fallen out of favour with Dom.
Guy requests Oliver's help with a patient, hoping to foster support for a new research proposal, Sacha's rabbi is taken seriously ill. Nina questions Matteo's feelings for her.
Oliver struggles with the thought that Tara's death could of been prevented, while Zosia is offered a chance to advance her career. Meanwhile, Lofty worries Dom still has feelings for him.
When events take a tragic turn during the Holby Half Marathon, Lofty is forced to finally confront his feelings for Dom and Fletch must enlist Jac's help to treat a patient.
Hanssen is forced to confront his past when a familiar face arrives as a registrar, and Zosia finally relaxes into some wedding planning, but Guy's behaviour sparks fresh concern.
As Guy's behaviour becomes increasingly erratic, Zosia's concerns put her in an impossible position, and Donna is shocked when her patient has a surprising visitor.
It is the day of Oliver and Zosia's wedding, and as the family and friends gather, the arrival of a particular guest threatens to ruin their happy day.
In the aftermath of the wedding, Zosia has a hard decision to make, while Dom and Lofty are in an awkward situation when Dom's boyfriend turns up on Keller.
Matteo makes a stranger recognise Nina on the ward, and Fredrik tries to impress Hanssen, but only winds up testing his patience.
Fletch must deliver some bad news as the reality of being Director of Nursing set in, and the arrival of a familiar face leaves Essie contemplating an emotional farewell.
Fredrick and Sara need to convince Hanssen to give them his professional backing, and an impromptu visit from a loved one gives Raf food for thought.
Nina must decide if she can trust Fredrick when he discovers a secret that forces her to question her future with Matteo, and Oliver is haunted by a face from the past.
On the day of Ric's coroner's court hearing, Donna discovers contradictory evidence that threatens his defence, and Dom struggles to find reasons to find a research subject.
Hanssen finds an enexpected ally in Sacha as he battles to ensure Holby'survival, and an unwanted visitor compounds Donna's problems when she returns to work.
Oliver is determined to win funding for his chest wall rec0nstruction project, and Morven is faced with a shock from her past when she discovers the identity of Lofty's mystery patient.
With the merger decision hanging over the hospital, Fredrik had his own future at Holby firmly on his mind, and Donna's friendship with Rik takes an unexpected turn.
In light of Nina's news, Matteo can no longer run from their past, and Jac faces mounting pressures, both personal and professional. Meanwhile, an unwelcome visitor puts Donna in a tough position.
A new face arrival in Holby sets the wheels of a change in motion, Jac is forced to assess her personal and professional lives, and Raf is reminded of why he fell in love with medicine.
It remains to be seen how the staff will cope when a face from the past arrives with a chilling vendetta.
Dominic is determined to push new F1 Meena to the limit. With the hospital still recovering, Hanssen takes position at the front line on AAU.
An overworked Morven finds herself torn between her past and her future on Christmas Eve. Essie is surprised to bond with Gaskell over an unusual patient.