On a new year road trip to compete for funding, Jac, Ric and Sacha confront some old enemies. Serena's worst fears are realised.
A face from the past continues to wreak havoc when he returns to Holby. Nicky and Cameron go head to head when Jac offers one of them an opportunity for promotion. And Serena shepherds her flock down on AAU, when an old associate arrives and upsets the status quo.
Dominic desperately tries to inveigle his way into working alongside new Consultant, Ange Goddard, only to find that she's not that impressed with him. Meanwhile, Cameron bites off more than he can chew when he clashes with Jac, and Ric's ex-wife returns as a locum for the day, much to his dismay.
Frieda is happy that her life is back on an even keel, but her contentment is shattered when ex-boyfriend Roman unexpectedly reappears. With their relationship going well, Zav is keen to step up and ease the burdens weighing on a stressed Donna. But all does not entirely go to plan when he embarks on some impromptu parenting of Mia. Ange feels the pressure as she works to sell her vision for her Young Adult Unit while treating a difficult and vulnerable patient.
Ric goes above and beyond to treat his patients when Holby is overwhelmed by a winter crisis, while a grief-stricken Frieda immerses herself completely in her work, causing concern for Jac and Fletch. Ange has her work cut out on YAU thanks to an obstinate teenager, with Essie persuading her to enlist help from an unlikely source.
Can Ange convince her patient to proceed with a life-saving operation? A resolute Ric campaigns for change. Does Nicky have the strength to fight for what she wants?
While Holly's condition weighs heavily on an emotionally invested Ange, Holly's distraught parents must put their differences aside to make a heart-breaking decision. When new locum Chloe covers on Darwin a smitten Cameron sets out to impress. And when a disgruntled Xavier is tasked with treating spiritual Carole, it's clear she's not the only one in pain.
Zosia returns to Holby looking for work, while a frustrated Jac tries to track down Frieda. Elsewhere, Ange admits there is no hope for her patient, Holly, while Donna and Xavier clash over their new living arrangements.