Jac is confined to a psychiatric unit, and refuses to accept that she has a problem. However, a visit from Fletch, Sacha and Elliot convinces her that things have to change for Emma's sake. Chloe receives some life-changing news, and decides that she has to tell Evan's sister the truth about her dead brother. Zav and Cameron try to save the life of a girl who has been embraced, only to discover a disturbing truth behind the attack.
This series is a spin-off from the long running BBC medical drama Casualty. Set in the same hospital as its sister series, this show follows the everyday lives, professional and personal, of the doctors, nurses and patients who find themselves, for various reasons, in the wards of Holby City General Hospital