As DI Jane Archer investigates the recent deaths on Keller, Ric gambles away a small fortune to try and repair his relationship with his daughter. A patient is brought in who needs a gall-bladder operation desperately which has to be done at the Hadlington but her husband hasn't told her that they can't afford it.
As the police invstigations into the suspicious deaths continues, Stan Ashleigh is admitted to Holby with heart problems. In theatre Ric Griffin and Diane Lloyd ignore his requested DNR.
Chrissie finaly finds out about the relatioship between Owen and her mother and after a fight between the two, they both get suspended. As the police investigations continue a forensic psychologist is brought in to interrogate the hug suspects.
Ric is served with a reposession notice as he gambles away more od his money and Nic Yorke is still being held at the police station for the hug of two.
As Jess and Kelly go to visit Nic at the police station, Ric tries to hide his gambling debts and the fact that his home has been repossessed.
Having lost his home, Ric Griffin has been sleeping in his office.
When the police realise that Nic couldn't have been the murderer, he is released. Meanwhile, Rosies daughter is admitted to AAU after overdosing on her mother's iron tablets.
Jess finds out that her father has been sleeping in his office and she insists that he stays with her. Ric defends Kath from the board who want to suspend her and she is arrested.
Kelly wants Nic to run away with her, she finaly tells him the truth.
Nic and Kelly's mother is admitted with severe stab wounds and Nic thinks Kelly is responsible. Kelly promises that she will hand herself in to the police but later she trie to hug her mother again. Kath interrupts her and she chases her through the hospital until they are in a room alone together and Kelly stabs Kath.
Zubin Khan finds Kath bleeding to death in a room and Nic's mother finaly confesses to him.
There's a dramatic start to the festive season in Holby following the gas explosion, which has left siblings Nic and Kelly fighting for their lives. The pair are rushed into hospital, where Jess keeps a vigil by Nic's bedside, while Kelly is rushed into theatreâ-and for Ric, who knows his colleague is a deranged murderess, this proves a real test of his professionalism, as he resists the temptation to just let her die. On a lighter note, Tom hosts the Holby Christmas bash, where an inebriated Tricia makes a complete spectacle of herself, while ladies' man Mubbs surprisingly opts to give the party a miss and do a spot of babysitting for Rosie instead.
As Nic's condition worsens, he asks to see his sister before she is moved to a secure hospital. When he deteriorates he must be taken to theatre but cannot be saved.
Chrissie and Mubbs wake up together after their one night stand and Ed Keating finds out that his father will be released in a few weeks.
Ric performs a very high risk operation on a cancer patient and Diane thinks that it is for money. She decides to tell Tom about it and Ric is left feeling betrayed by her. Ric later reveals to Zubin that he took on the risk for kicks.
After gambling with the life if a patient, Zubin asks Ric to see a psychyatrist. Jess considers not going to Nic Yorke's funeral.
At Nic's funeral Jess is the only person from the hospital to be there. Nic's mother and a depressed Kelly are also there. Jess visits Kelly after the funeral but it doesn't go very well. When she returns, she receives the news that Kelly hanged herself and she is dead.
After a bad day for Tricia and Kath, Tricia invites Diane and Kath to the bar to get drunk. In maternity a young pregnant woman wants to give her baby for adoption immediately despite the fathers opinion.
Tom and Ed are caught in a dilemma over a transplant, whilst Rosie fears that her relationship with Mubbs has alienated her children. A quirky but handsome new arrival brightens Kath's day.
A shock admission to Darwin finds Chrissie struggling to keep a secret from Ed, and Ric has some surprising news for Jess.
George's condition pushes Ed and Tom's professional relationship to the brink. And Rick and Diane get close over a case.
The custody battle draws near for Rosie. Ed could face Tom's wrath once more. Alarm bells ring for Diane as she talks to a young girl and her father.
Mubbs discovers where he really stands with Rosie. Ed throws out the rule book for his dad. And Diane is working with her new flame.
Keller's new nurse spells trouble for Diane and Owen finds his hands full with her best mate. Jess finds it hard to resist a patient.
Ric does not approve of his daughter's new boyfriend Robert Pullman and Kath and Chrissie compete for the job of Clinical Matron. Ric discovers a rare cancer in Jack Fenton which he thinks he must have contracted from work.
Kath has doubts about taking up her new job and decides to do something different. She has a leaving party at the bar where she tells Lisa about how her father died. Meanwhile, Rosie breaks up with Mubbs and Jess Breaks up with Robert Pullman.
Tom and Ed treat young woman with a strangely high blood pressure and heart problem and Robert Pullman is readmitted with a bicycle accident injury but Ric doesn't belive him.
When Mubbs considers leaving his job, Rosie tells him that she loves him. Tom performs an operation on a high risk patient against Zubins wishes and a woman has a miscarriage which Mubbs discovers is because of her condition.
Diane Lloyd goes to an army hospital to advise on surgical techniques during a live-fire exercise. While she is there a soldier is shot and she must save him. A pregnant woman with a weak heart is in to give birth against Owens advice.
As Ric attends his bankruptcy court hearing, Jess goes home after a stressful day and reluctantly lets Robert Pullman accompany her. Things get unhappy when he admits that he stole her keys and delibrately caused his girlfriends death. He gets pushed through a window which causes him severe bleeding and he is taken to Holby where Ric operates on him unaware of the situation. Meanwhile in maternity, Mubbs and Owen treat a pregnant woman with syphilis.
The new, almost arrogant registrar, Will Curtis arrives on his first day and he doesn't go un-noticed.
After he tries to get a transplant patient to the top of the list Ed is suspended. Sammi is admitted to AAU with a bleeding ulcer and Rosie goes to see him after Mubbs proposes to her. Cherise Patterson's pregnancy becomes complicated when she shows symptoms related to cancer and she goes into labour during Mubbs' investigations.
At Ed's suspension hearing, Chrissie refuses to cover for him and Tom, Ric and Zubin try to separate conjoined twins. When problems arise, Tom tries to get the permission of the parents to continue but when he fails to he continues anyway which results in him having to resign. Meanwhile, Lisa is offered the position of Ward Sister on Keller.
On the first anniversary of the death of Chrissie's baby, Mubbs tells her that Owen was the father and Lisa Fox starts her first day in charge of Keller ward with her hands full.
The new cardiothoracic consultant Connie Beauchamp arrives and is greated by the not very welcoming attitude of Will who is not very happy that he now has a female boss. And after a day of flirting with Ric, she sleeps with him in his office after which she reveals to him that she is the new Medical Director, making her his boss.
Diane's pregnant sister is brought in to Holby after being in a car crash. As she deteriorates, her and her unborn baby's life are hanging in the balance.
Rosie gets some good news but Mubbs does not seem as enthusiastic about it. Meanwhile, Diane's sister's condition worsens and her baby must be delivered by cesarean. After the baby has been delivered, Joanna dies.
Diane struggles on her first day back after her sister's death. Will's bedside manner needs improving, and Connie digs around in his past.
Ric is shocked when he sees Connie working her magic with Zubin and even more so after seeing her flirting with Mubbs. Meanwhile, Lisa tries to convince Mickie and Donna to stop being so irresponsible.
Mickie and Donna wake up in bed together after their night of passion but it is later discovered that it meant more to Mickie. Meanwhile, Zubin is upset when he finds out that Connie wants operate on a woman who happens to be the wife of an important trust member.
Diane's babysitter calls in sick and Diane is forced to take the baby in to work with her which doesn't go down well with Connie who tells her that she must choose between a child and her career. Rosie and Mubbs make up and Donna and Mickie become friends again.
Connie organizes an evening of cricket for the men in order to build their abilities to work in a team, but they abandon that plan and decide to play some drinking games instead. Meanwhile, a plastic surgeon is treating a patient on the ward and Lisa is forced to evict Donna when she fails to pay the rent.
As Zubin starts making plans for the hospital, Donna confides her problems in Chrissie who is very upset after being set up with Carlos by Tricia. Meanwhile, Diane discovers that Jack's father wants custody of his son.
Zubin and Ric give a lecture at Holby City University which is attended by Ric's son, Leo and his pregnant girlfriend who happens to be a drug addict. She goes into premature labor and the baby must be delivered by cesarean section.
Connie observes Will for the day after receiving numerous complaints from patients about his attitude. The situation is made worse when a patient makes a complaint to the board.
Will's disciplinary hearing puts his career in question but will Connie come to save him? Tricia and Carlos' relationship progresses.
Jess confides in Donna that she has a crush on an older man but Donna is soon telling everyone. Mubbs is not supportive of Mickie's dream to go to medical school and Owen asks Diane to move in with him.
At Ric's 50th birthday party, both personal and professional relationships are tested. Chrissie's attempts to stop Owen's relationship with Diane backfire and Connie proves that she will go to any lengths to prove a point.