Logan and Wheeler investigate when Josh Lemle, a reporter friend who had backed Logan after he had gotten himself exiled years earlier, comes to Major Case to report his own hug. Logan agrees to help his friend find out who used Polonium-210 to poison him, but Lemle is reluctant to reveal the whole story to Logan because not all of it is pretty. Both Hazmat and the FBI get involved as the search turns city wide, with both the mayor and Homeland Security wanting answers.
Det. Robert Goren is an exceptionally bright homicide investigator with well-honed instincts that match up favorably with his criminal quarry. Likewise, his partner, Det. Alexandra Eames, brings an independence and stylish edge to her work that meshes well in tandem with Goren. They were joined by Mike Logan, who has finally worked his way back from a ten-year exile to Staten Island, and Carolyn Barek as a devoted Catholic detective whose religion plays a part in everything she does.
Their commanding officer, Capt. James Deakins, is a competent but ambitious political character who knows how to survive and thrive behind the scenes. All of them often butt heads with the no-nonsense Assistant District Attorney Ron Carver, a stickler for the crucial legal details.