Polaris' baby begins to suffer from a deadly illness, leaving the Inner Circle unable to heal her, and prompting them to turn to an unexpected source for help. Meanwhile, Reed and Lauren take an excursion to deliver illegal meds, but Reed's powers complicate their plans. Then, Thunderbird and Blink meet the leader of the Morlocks - a shadowy group of mutants that live underground - who offers to help them find the Inner Circle, but the two factions may not have the same goals.
The lives of an ordinary suburban family change course forever when they discover their children have developed mutant powers. When the threat of a hostile government forces the family to go on the run to protect themselves, they join the ranks of an underground network of mutants. Together, the group fight to survive in a world where fear and misunderstanding put them at constant risk.