A patient's exposure to radiation sends the Night Shift into chaos. Topher implements an immediate quarantine and locks down the ER. Paul cares for the quarantined patient with the help of Ragosa and Kenny. Meanwhile, TC, Drew, and Gwen race to the site of a multi-victim car cash, where they discover an injured police officer at the heart of the accident. Back at the hospital TC and Jordan work desperately to save the officer's life using an unconventional procedure. TC gets an unwelcome surprise when his troubled sister-in-law Annie shows up out of the blue. Still adrift and grieving over the death of her husband, Annie is eager to reminisce with TC about the good old days. Meanwhile, a former patient harasses Jordan, and Drew struggles with his recent breakup. Joey pushes Krista to take her future into her own hands.
Season 2 Episode 5 of The Night Shift was watched by 5,440,000 viewers, resulting in a 1.50 rating in the 18-49 demographic.
Welcome to the night shift, where every day is a fight between the heroic efforts of saving lives and the hard truths of running a hospital. At San Antonio Memorial, the men and women who work the wee hours are a special breed, particularly adrenaline junkie T.C. Callahan. After a grueling tour of duty in the Middle East, T.C. is about to learn that his toughest battles will be fought right at home. He and his irreverent team of late-night docs, including Topher and Drew, know how to let off steam with the casual prank or two, but when lives are at stake they are all business.
Unfortunately, the night shift is now under new management and boss Michael Ragosa is more interested in cutting costs than helping people. But T.C. has never met a rule he couldn't break, or a person he won't stand up to. And it's clear that not even Dr. Jordan Santos, T.C'.s ex-girlfriend and now Ragosa's second in charge, has a chance at keeping him in line. If Ragosa wants a war, he'll get one.