Teaser: Stephanie, Michelle, Danny, and the "Bicycle bus". Main Synopsis: Danny has a new girlfriend named Denise, and he invites Denise and her two friends Zoey and Cheryl over to the house so Zoey and Cheryl can meet Jesse and Joey while D.J. is upstairs keeping an eye on Stephanie and Michelle. It turns out that Denise is a woman that Jesse once dated, and this has Danny wondering if there could possibly be a woman in San Francisco that Jesse hasn't dated. Zoey doesn't like Joey's jokes, but Joey and Cheryl get along with each other just fine. Danny is depressed because Denise is still hung up on Jesse and she can't get her mind off of Jesse because she thinks she and Jesse have an opportunity to get back together, until a talk with Jesse finally has Denise coming to her senses. Meanwhile, Stephanie causes D.J. to accidentally drop Danny's wedding ring down the drain in the upstairs bathroom sink. With a little work, Denise and the guys help D.J. and Stephanie get the ring back.
After his wife is killed in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.