Teaser: A stretching show for Stephanie, Becky, and the twins. Main Synopsis: Mrs. Carruthers drops by and tells Joey that a substitute teacher is needed for Michelle's class at school, so Joey volunteers to do it, since it gives him an opportunity to use the teaching license that he has been regularly renewing. Michelle thinks it's going to be fun to have Joey as the substitute, but she's not laughing when Joey sends her to the principal's office for acting up during class. Michelle then gets the class to agree to give Joey the silent treatment. Joey tricks the class into talking to him again, and Michelle admits that Joey is so funny that she had forgotten that sometimes he has to be serious. Meanwhile, Jesse is forming a new band and he has hired a guitarist named Viper. D.J. becomes attracted to Viper.
After his wife is killed in a car accident, news anchorman Danny Tanner recruits his brother-in-law Jesse Katsopolis (a rock musician) and best friend Joey Gladstone (who works as a stand-up comedian) to help raise his three young daughters: D.J., Stephanie, and Michelle, in his San Francisco home. Over time, the three men as well as the children bond and become closer to one another.
Danny is reassigned from his duties as sports anchor by his television station to become co-host of a local morning television show, Wake Up, San Francisco, and is teamed up with Nebraska native Rebecca Donaldson.