Meredith and the team are focused on helping Owen's sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire, and the doctors are introduced to a few new faces that spice things up around the hospital.
Meredith struggles to come up with a new plan for Owen's sister. Jo makes a surprising choice regarding Alex, and Andrew's sister's controversial research leads to a shocking discovery.
Harper Avery arrives at Grey Sloan, putting Bailey on edge. A familiar face from Meredith's past returns as a patient, and Amelia tries to manage a secret.
Amelia confronts a difficult situation, while Meredith deals with the fallout from her conversation with Nathan. Maggie finds herself at an awkward family dinner, Jackson receives big news and Richard and Bailey search for the stars of tomorrow.
In a flashback to Iraq in 2007, the events leading up to Megan's kidnapping are revealed. In present day, Owen and Megan hash out old wounds.
Jackson invites the guys to relax with him on a day at sea; Arizona, April, and Maggie treat a woman who is hiding a deadly secret.
After a roller coaster car falls off the track at the county fair, the doctors at Grey Sloan tend to patients who spark memories about ghosts from their past.
A hacker compromises the hospital's computer system, causing monitors, phones, labs and patient files to all go down. As technology fails them, Bailey attempts to keep the peace but chaos erupts and the doctors are forced to get creative in their methods to treat the patients.
Jo finally faces her estranged, abusive husband Paul Stadler, while Grey Sloan continues to work with the FBI after a hacker has compromised the hospital's computer system.
A young boy is admitted to Grey Sloan Memorial and his case has a profound impact on the doctors. Meanwhile, April is faced with a surprising patient, and Jo continues to deal with her estranged husband.
The stress of managing the hospital and coming to terms with Ben's decision to become a Seattle firefighter pushes Bailey to her limits.
April is in charge of the new Grey Sloan Surgical Innovation Contest, and the doctors are eager to start their projects. Meanwhile, Catherine's old friend has a shocking idea for Catherine and Jackson; and Meredith treats a returning patient who inspires her project.
Seattle firefighters Ben Warren and Andy Herrera head to Grey Sloan after rescuing two boys that are injured in a house fire. With one of the boys' lives literally in Andy's hands, her skills are put to the test. Meanwhile, the doctors are hard at work on their projects for the Grey Sloan Surgical Innovation Contest; and Amelia brings Tom Koracick in to consult on her and Alex's patient.
Maggie's relationship with Clive starts to progress, and she invites him over for a game night to meet Meredith and Amelia. Meredith and Jo meet with the owner of the patent to the polymer they need for their project, who coincidentally is a friend of the family.
Meredith tries to learn more about Marie Cerone's history with her mother. Meanwhile, Jo is applying for fellowships around the country and it throws Alex for a loop; and Tom Koracick helps April acknowledge her crisis of faith.
Maggie and Jackson are enjoying spending time together, but he must turn his concentration toward the groundbreaking vaginoplasty surgery he has scheduled with Catherine and Richard. Meanwhile, Meredith and Jo hit a roadblock with their contest submission, so Jo helps Bailey with an incoming trauma patient who used to be an astronaut.
April's crisis of faith is challenged by a patient she treats who is a rabbi, and Meredith treats a patient who is a transplant surgeon from another hospital.
Amelia, Koracick and DeLuca perform a risky procedure to remove a young patient's brain tumor; Meredith and Jo work with different polymers to try to salvage their project submission; Richard's AA sponsor is admitted to Grey Sloan with a DNR.
An agent from ICE shows up at Grey Sloan in search of an employee who may be working in the U.S. under DACA. Alex's patient Kimmie wants to leave the hospital to enjoy her final days, but Alex feels differently. Meanwhile, Arizona treats Matthew Taylor's baby and April wants to do whatever she can to help.
During presentations on Grey Sloan Surgical Innovation Prototypes Day, Arizona shares some cookies from an appreciative patient that, unbeknownst to her, contain a special ingredient. Meanwhile, Catherine reveals some shocking details to Jackson about his grandfather's past; and Jo steps in mid-operation on a major surgery after Bailey and Meredith are down for the count.
The hospital brings in crisis management to help sort out allegations against Harper Avery; nurse Olivia shows up at Grey Sloan with her son, throwing Alex and Jo for a loop; Sofia is having a hard time at school.
Alex and Jo go on a road trip to Iowa to find Alex's mom, whom he hasn't heard from in a very long time. Meanwhile, Meredith gives a presentation on her mini-livers project, which attracts a ton of attention, and Jackson works to rebuild the foundation after its reputation is threatened.
One of Grey Sloan Memorial's own is seriously injured, making the team reflect on what is truly important to them. Meanwhile, Nicole Herman pays a visit to GSM and talks to Arizona about an exciting opportunity.
Meredith Grey and the team of doctors at Grey Sloan Memorial are faced with life-or-death decisions on a daily basis. They seek comfort from one another, and, at times, more than just friendship. Together they discover that neither medicine nor relationships can be defined in black and white.