When one of the doctors is shot outside the hospital, the ER is put into lockdown and the team races to save one of their own. Elsewhere, Devon and The Raptor work with a patient who learns he is unable to receive a lung transplant, due to his vaccination status. Meanwhile, Devon and Leela try to juggle the new dynamics of their relationship and Cade's father arrives at Chastain.
Conrad Hawkins is one of Chastain Park Memorial Hospital's best doctors. Charming and arrogant, Conrad likes to take an unconventional approach whenever possible and believes it's his personal duty to shatter the romantic illusions of the first-year residents. Dr. Devon Pravesh is an innocent idealist who leans on his finely tuned moral compass, but with Conrad's help, he begins to realize that the practice of medicine is a business, like any other, with less-than-angelic patients and fallible doctors. Lives may be saved or lost, but expectations will always be shattered.